Literature DB >> 9330716

The beta subunit, Kv beta 1.2, acts as a rapid open channel blocker of NH2-terminal deleted Kv1.4 alpha-subunits.

R L Rasmusson1, S Wang, R C Castellino, M J Morales, H C Strauss.   

Abstract

A recently discovered class of ancillary subunits has been shown to modify the inactivation properties of alpha-subunits belonging to the Kv1 family of potassium channels. One of these subunits, Kv beta 1.2, modifies intrinsic alpha-subunit C-type inactivation. N-type inactivation and open channel block have been proposed to increase the rate of development of C-type inactivation. We demonstrate here that Kv beta 1.2 has kinetic properties which are consistent with rapid open channel block.

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Year:  1997        PMID: 9330716     DOI: 10.1007/978-1-4615-5959-7_3

Source DB:  PubMed          Journal:  Adv Exp Med Biol        ISSN: 0065-2598            Impact factor:   2.622


  9 in total

Review 1.  K+ channels in apoptosis.

Authors:  E D Burg; C V Remillard; J X-J Yuan
Journal:  J Membr Biol       Date:  2006-04-17       Impact factor: 1.843

Review 2.  Modification of K+ channel-drug interactions by ancillary subunits.

Authors:  Glenna C L Bett; Randall L Rasmusson
Journal:  J Physiol       Date:  2007-12-20       Impact factor: 5.182

3.  Structural dynamics of an isolated voltage-sensor domain in a lipid bilayer.

Authors:  Sudha Chakrapani; Luis G Cuello; D Marien Cortes; Eduardo Perozo
Journal:  Structure       Date:  2008-03       Impact factor: 5.006

4.  Functional ion channels in human pulmonary artery smooth muscle cells: Voltage-dependent cation channels.

Authors:  Amy L Firth; Carmelle V Remillard; Oleksandr Platoshyn; Ivana Fantozzi; Eun A Ko; Jason X-J Yuan
Journal:  Pulm Circ       Date:  2011-01-01       Impact factor: 3.017

5.  Inactivation of BK channels mediated by the NH(2) terminus of the beta3b auxiliary subunit involves a two-step mechanism: possible separation of binding and blockade.

Authors:  C J Lingle; X H Zeng; J P Ding; X M Xia
Journal:  J Gen Physiol       Date:  2001-06       Impact factor: 4.086

6.  Acute hypoxia selectively inhibits KCNA5 channels in pulmonary artery smooth muscle cells.

Authors:  Oleksandr Platoshyn; Elena E Brevnova; Elyssa D Burg; Ying Yu; Carmelle V Remillard; Jason X-J Yuan
Journal:  Am J Physiol Cell Physiol       Date:  2005-10-19       Impact factor: 4.249

7.  Inactivation of BK channels by the NH2 terminus of the beta2 auxiliary subunit: an essential role of a terminal peptide segment of three hydrophobic residues.

Authors:  Xiao-Ming Xia; J P Ding; Christopher J Lingle
Journal:  J Gen Physiol       Date:  2003-02       Impact factor: 4.086

8.  Stereospecific binding of a disordered peptide segment mediates BK channel inactivation.

Authors:  Vivian Gonzalez-Perez; Xu-Hui Zeng; Katie Henzler-Wildman; Christopher J Lingle
Journal:  Nature       Date:  2012-05-03       Impact factor: 49.962

9.  S-glutathionylation of an auxiliary subunit confers redox sensitivity to Kv4 channel inactivation.

Authors:  Henry H Jerng; Paul J Pfaffinger
Journal:  PLoS One       Date:  2014-03-27       Impact factor: 3.240

  9 in total

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