Literature DB >> 9330615

Characterization of a human homolog of (6-4) photolyase.

T Todo1, H Tsuji, E Otoshi, K Hitomi, S T Kim, M Ikenaga.   

Abstract

(6-4)Photolyase catalyzes light-dependent repair of UV-induced pyrimidine (6-4) pyrimidone photoproducts. A human cDNA clone which has high sequence homology to the (6-4)photolyase gene (H64PRH gene) was identified. In this paper we also isolated a genomic clone corresponding to the H64PRH cDNA and mapped it to chromosome 12q24.1 by fluorescence in situ hybridization (FISH). Northern-blot analysis revealed transcription of this gene in all human tissues examined. The H64PRH protein was overproduced in E. coli, partially purified and characterized. Like (6-4)photolyase, the enzyme contains two chromophores, one of which is FAD. However, the enzyme does not show any detectable photolyase activity.

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Year:  1997        PMID： 9330615     DOI： 10.1016/s0921-8777(97)00032-3

Source DB:  PubMed          Journal:  Mutat Res        ISSN： 0027-5107            Impact factor:   2.433


  8 in total

1.  Bacterial cryptochrome and photolyase: characterization of two photolyase-like genes of Synechocystis sp. PCC6803.

Authors:  K Hitomi; K Okamoto; H Daiyasu; H Miyashita; S Iwai; H Toh; M Ishiura; T Todo
Journal:  Nucleic Acids Res       Date:  2000-06-15       Impact factor: 16.971

2.  Enzyme plus light therapy to repair DNA damage in ultraviolet-B-irradiated human skin.

Authors:  H Stege; L Roza; A A Vink; M Grewe; T Ruzicka; S Grether-Beck; J Krutmann
Journal:  Proc Natl Acad Sci U S A       Date:  2000-02-15       Impact factor: 11.205

3.  ORF90, a Gene Required for Photoreactivation in Rhodobacter capsulatus SB1003 Encodes a Cyclobutane Pyrimidine Dimer Photolyase.

Authors:  Stephan Braatsch; Gabriele Klug
Journal:  Photosynth Res       Date:  2004-02       Impact factor: 3.573

4.  Differential regulation of mammalian period genes and circadian rhythmicity by cryptochromes 1 and 2.

Authors:  M H Vitaterna; C P Selby; T Todo; H Niwa; C Thompson; E M Fruechte; K Hitomi; R J Thresher; T Ishikawa; J Miyazaki; J S Takahashi; A Sancar
Journal:  Proc Natl Acad Sci U S A       Date:  1999-10-12       Impact factor: 11.205

5.  New role of zCRY and zPER2 as regulators of sub-cellular distributions of zCLOCK and zBMAL proteins.

Authors:  Jun Hirayama; Itsuki Fukuda; Tomoko Ishikawa; Yuri Kobayashi; Takeshi Todo
Journal:  Nucleic Acids Res       Date:  2003-02-01       Impact factor: 16.971

Review 6.  UV Protection in the Cornea: Failure and Rescue.

Authors:  Thomas Volatier; Björn Schumacher; Claus Cursiefen; Maria Notara
Journal:  Biology (Basel)       Date:  2022-02-10

Review 7.  Mitochondrial Genetic and Epigenetic Regulations in Cancer: Therapeutic Potential.

Authors:  Alexandra Wagner; Helena Kosnacova; Miroslav Chovanec; Dana Jurkovicova
Journal:  Int J Mol Sci       Date:  2022-07-18       Impact factor: 6.208

Review 8.  Formation and Recognition of UV-Induced DNA Damage within Genome Complexity.

Authors:  Philippe Johann To Berens; Jean Molinier
Journal:  Int J Mol Sci       Date:  2020-09-12       Impact factor: 5.923
  8 in total

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