Evaluation of cerebral arterial flow with transcranial Doppler ultrasound: theoretical development and phantom studies.

Blood flow information available from transcranial Doppler ultrasound is usually derived from velocity alone because no knowledge of vessel caliber is available. In cases such as vasospasm, where vessel size changes, the inference of flow from velocity becomes questionable. A computational technique was used to calculate a flow index and 2 vessel area indices based on the first and zero moments of the Doppler power spectrum. These indices were tested in a steady and pulsatile flow phantom using 6 different diameter elastic tubes. Changes in the flow index showed good agreement with changes in timed volume flow for different flow rates. The vessel caliber indices correctly predicted changes in area when different diameter tubes were examined. These indices may prove useful in clinical settings where the constancy of flow or vessel diameter between studies are in question.