| Literature DB >> 9328157 |
H de Graaf1, W V Dolsma, P H Willemse, W T van der Graaf, D T Sleijfer, E G de Vries, N H Mulder.
Abstract
Cardiac function was evaluated in 86 breast cancer patients after standard chemotherapy, followed by ablative chemotherapy and chest irradiation. One patient died of subacute heart failure 3 months after ablative chemotherapy. At a minimum of 1 year's follow-up (range 1-11 years) left vertricular ejection fraction (LVEF) was marginally abnormal in 4 of 27 disease-free survivors. One exceptional patient who received two transplantations is alive, with serious heart failure occurring after the second ablative chemotherapy. Including this patient, the percentage of patients free of clinical and subclinical cardiac dysfunction at 7 years is 78% (95% CI 61-95%). After ablative chemotherapy, cardiotoxicity was rarely life-threatening. The impact of subclinical cardiotoxicity in the long term is not clear and needs continued evaluation.Entities:
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Year: 1997 PMID： 9328157 PMCID： PMC2228075 DOI： 10.1038/bjc.1997.489
Source DB: PubMed Journal: Br J Cancer ISSN： 0007-0920 Impact factor: 7.640