Literature DB >> 9328148

Expression of the DNA mismatch repair proteins hMLH1 and hPMS2 in normal human tissues.

D Fink1, S Nebel, S Aebi, H Zheng, H K Kim, R D Christen, S B Howell.   

Abstract

hMLH1 and hPMS2 are part of the DNA mismatch repair complex. Mutations in these genes have been linked to hereditary non-polyposis colon cancer; they also occur in a variety of sporadic cancers. Western blot analysis and immunohistochemistry demonstrated that hMLH1 and hPMS2 are widely expressed nuclear proteins with a distribution pattern very similar to that previously described for hMSH2. These observations showing similar localization of hMLH1 and hPMS2 with hMSH2 are consistent with the biochemical function of these proteins in DNA mismatch repair.

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Year:  1997        PMID： 9328148      PMCID： PMC2228055          DOI： 10.1038/bjc.1997.480

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  13 in total

1.  Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis.

Authors:  S M Baker; C E Bronner; L Zhang; A W Plug; M Robatzek; G Warren; E A Elliott; J Yu; T Ashley; N Arnheim; R A Flavell; R M Liskay
Journal:  Cell       Date:  1995-07-28       Impact factor: 41.582

2.  Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologs.

Authors:  G M Li; P Modrich
Journal:  Proc Natl Acad Sci U S A       Date:  1995-03-14       Impact factor: 11.205

3.  Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer.

Authors:  C E Bronner; S M Baker; P T Morrison; G Warren; L G Smith; M K Lescoe; M Kane; C Earabino; J Lipford; A Lindblom
Journal:  Nature       Date:  1994-03-17       Impact factor: 49.962

4.  Human chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces N-methyl-N'-nitro-N-nitrosoguanidine tolerance in colon tumor cells with homozygous hMLH1 mutation.

Authors:  M Koi; A Umar; D P Chauhan; S P Cherian; J M Carethers; T A Kunkel; C R Boland
Journal:  Cancer Res       Date:  1994-08-15       Impact factor: 12.701

5.  The mismatch-repair protein hMSH2 binds selectively to DNA adducts of the anticancer drug cisplatin.

Authors:  J A Mello; S Acharya; R Fishel; J M Essigmann
Journal:  Chem Biol       Date:  1996-07

6.  Clues to the pathogenesis of familial colorectal cancer.

Authors:  L A Aaltonen; P Peltomäki; F S Leach; P Sistonen; L Pylkkänen; J P Mecklin; H Järvinen; S M Powell; J Jen; S R Hamilton
Journal:  Science       Date:  1993-05-07       Impact factor: 47.728

7.  The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer.

Authors:  R Fishel; M K Lescoe; M R Rao; N G Copeland; N A Jenkins; J Garber; M Kane; R Kolodner
Journal:  Cell       Date:  1993-12-03       Impact factor: 41.582

8.  GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cells.

Authors:  F Palombo; P Gallinari; I Iaccarino; T Lettieri; M Hughes; A D'Arrigo; O Truong; J J Hsuan; J Jiricny
Journal:  Science       Date:  1995-06-30       Impact factor: 47.728

9.  Mutations of two PMS homologues in hereditary nonpolyposis colon cancer.

Authors:  N C Nicolaides; N Papadopoulos; B Liu; Y F Wei; K C Carter; S M Ruben; C A Rosen; W A Haseltine; R D Fleischmann; C M Fraser
Journal:  Nature       Date:  1994-09-01       Impact factor: 49.962

10.  MLH1, PMS1, and MSH2 interactions during the initiation of DNA mismatch repair in yeast.

Authors:  T A Prolla; Q Pang; E Alani; R D Kolodner; R M Liskay
Journal:  Science       Date:  1994-08-19       Impact factor: 47.728
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  9 in total

1.  Dimerization of MLH1 and PMS2 limits nuclear localization of MutLalpha.

Authors:  Xiaosheng Wu; Jeffrey L Platt; Marilia Cascalho
Journal:  Mol Cell Biol       Date:  2003-05       Impact factor: 4.272

2.  Expression of the hMLH1 and hMSH2 proteins in normal tissues: relationship to cancer predisposition in hereditary non-polyposis colon cancer.

Authors:  Pavlína Plevová; Eva Sedláková; Jana Zapletalová; Anna Krepelová; Petra Skýpalová; Zdenek Kolár
Journal:  Virchows Arch       Date:  2004-12-10       Impact factor: 4.064

3.  Conventional and tissue microarray immunohistochemical expression analysis of mismatch repair in hereditary colorectal tumors.

Authors:  Yvonne Hendriks; Patrick Franken; Jan Willem Dierssen; Wiljo De Leeuw; Juul Wijnen; Enno Dreef; Carli Tops; Martijn Breuning; Annette Bröcker-Vriends; Hans Vasen; Riccardo Fodde; Hans Morreau
Journal:  Am J Pathol       Date:  2003-02       Impact factor: 4.307

4.  Cell-selective biological activity of rhodium metalloinsertors correlates with subcellular localization.

Authors:  Alexis C Komor; Curtis J Schneider; Alyson G Weidmann; Jacqueline K Barton
Journal:  J Am Chem Soc       Date:  2012-11-08       Impact factor: 15.419

5.  In silico and in vivo splicing analysis of MLH1 and MSH2 missense mutations shows exon- and tissue-specific effects.

Authors:  Patrizia Lastella; Nicoletta Concetta Surdo; Nicoletta Resta; Ginevra Guanti; Alessandro Stella
Journal:  BMC Genomics       Date:  2006-09-22       Impact factor: 3.969

6.  Expression of hMSH2 protein of the human DNA mismatch repair system in oral lichen planus.

Authors:  Flávio Juliano Garcia Santos Pimenta; Maria das Graças Rodrigues Pinheiro; Ricardo Santiago Gomez
Journal:  Int J Med Sci       Date:  2004-08-05       Impact factor: 3.738

7.  Immunohistochemical analysis of expression and allelotype of mismatch repair genes (hMLH1 and hMSH2) in bladder cancer.

Authors:  H S Kassem; J M Varley; S M Hamam; G P Margison
Journal:  Br J Cancer       Date:  2001-02-02       Impact factor: 7.640

8.  Expression of hMLH1 and hMSH2 proteins in ameloblastomas and tooth germs.

Authors:  R Bologna-Molina; V Pereira-Prado; C Sánchez-Romero; G Tapia-Repetto; S Soria; M Hernandez; R Gónzalez-Gónzalez; M Molina-Frechero; T Mikami
Journal:  Med Oral Patol Oral Cir Bucal       Date:  2018-03-01

9.  Microsatellite instability and intratumoural heterogeneity in 100 right-sided sporadic colon carcinomas.

Authors:  C Chapusot; L Martin; A M Bouvier; C Bonithon-Kopp; A Ecarnot-Laubriet; D Rageot; T Ponnelle; P Laurent Puig; J Faivre; F Piard
Journal:  Br J Cancer       Date:  2002-08-12       Impact factor: 7.640
  9 in total

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