| Literature DB >> 9328036 |
A Aperia1, A C Eklöf, U Holtbäck, S Nowicki, M Sundelöf, P Greengard.
Abstract
Intrarenally formed dopamine induced natriuresis by inhibiting the activity of renal tubular Na/KATPase. This effect is mediated via a complex signal network, which includes inhibition of PP1 via the adenylyl cyclase-PKA-DARPP32 pathway and activation of PKC via the PLA2-arachidonic acid-20HETE pathway. The renal dopamine availability is a major determinant of the natriuretic effect of dopamine and is to a large extent modulated by the activity of COMT. The possibility that regulation of dopamine storage and release influences renal dopamine effects should be considered.Entities:
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Year: 1998 PMID： 9328036 DOI： 10.1016/s1054-3589(08)60885-6
Source DB: PubMed Journal: Adv Pharmacol ISSN： 1054-3589