Functional brain imaging and the neuropathology of schizophrenia.

We know much more about the anatomy of the frontal lobes than we do about their functions or how these functions go wrong in schizophrenia. Key areas for brain imaging research that will increase our understanding of frontal function concern (1) long-range functional connectivity and the mechanisms by which one brain region modulates activity in another and (2) the mechanisms underlying specific signs and symptoms associated with schizophrenia.