Literature DB >> 9327442

Theory of force transducer design optimization for die wall stress measurement during tablet compaction: optimization and validation of split-web die using finite element analysis.

C Yeh1, S A Altaf, S W Hoag.   

Abstract

PURPOSE: 1) To illustrate how computer aided engineering stress analysis can be used to improve the transducer design process for tablet press instrumentation; 2) to use these optimal design procedures for the geometric optimization of a cylindrical, segmented, and a novel split-web die design. Discussion includes the selection of optimal die wall thickness, segment cutting angle, strain gage placement, Wheatstone bridge configuration, and the influence of tablet height and position within the die on signal output.
METHODS: Stress analysis was done with a finite element analysis (FEA) software package running on a personal computer.
RESULTS: For the segmented die, the admissible range of die wall thicknesses depends upon cutting angle; the signal output is non-linear because the stress distribution in the die wall is influenced by tablet height and position within the die. For the split-web die, the optimal configuration consists of a 1/8 in. sensing web with a strain gage located at the peak of the sensing-web arch. This prototype had a linear calibration curve (r2 = 0.999) with no hysteresis. Radial versus axial stress transmission curves for: starch and sodium chloride were consistent with literature data.
CONCLUSIONS: Finite element analysis (FEA) is a useful numerical tool for the systematic optimization of tablet press instrumentation. By enclosing the sensing web of a three layered die design in a cylinder, the split-web design can be directly mounted without modification of the die table.

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Year:  1997        PMID: 9327442     DOI: 10.1023/a:1012194504982

Source DB:  PubMed          Journal:  Pharm Res        ISSN: 0724-8741            Impact factor:   4.200


  11 in total

1.  PHYSICS OF TABLET COMPRESSION. XIII. DEVELOPMENT OF DIE-WALL PRESSURE DURING COMPRESSION OF VARIOUS MATERIALS.

Authors:  J J WINDHEUSER; J MISRA; S P ERIKSEN; T HIGUCHI
Journal:  J Pharm Sci       Date:  1963-08       Impact factor: 3.534

2.  The physics of tablet compression. X. Mechanism of action and evaluation of tablet lubricants.

Authors:  W A STRICKLAND; T HIGUCHI; L W BUSSE
Journal:  J Am Pharm Assoc Am Pharm Assoc       Date:  1960-01

3.  The physics of tablet compression. IV. Relationship of ejection, and upper and lower punch forces during compressional process: application of measurements to comparison of tablet lubricants.

Authors:  E NELSON; S M NAQVI; L W BUSSE; T HIGUCHI
Journal:  J Am Pharm Assoc Am Pharm Assoc       Date:  1954-10

4.  The physics of tablet compression. VIII. Some preliminary measurements of die wall pressure during tablet compression.

Authors:  E NELSON
Journal:  J Am Pharm Assoc Am Pharm Assoc       Date:  1955-08

5.  [Measurement of radial forces using divided matrices. Application of pharmaceutical problems].

Authors:  U Conte; P Colombo; A La Manna; C Caramella
Journal:  Farmaco Prat       Date:  1977-11

6.  The application of photoelastic techniques to a rotary tabletting machine.

Authors:  K Ridgway; P H Rosser
Journal:  J Pharm Pharmacol       Date:  1971-12       Impact factor: 3.765

7.  Magnesium lauryl sulfate in tableting: effect on ejection force and compressibility.

Authors:  A M Salpekar; L L Augsburger
Journal:  J Pharm Sci       Date:  1974-02       Impact factor: 3.534

8.  The effect of particle shape and crystal habit on properties of sodium chloride.

Authors:  E Shotton; B A Obiorah
Journal:  J Pharm Pharmacol       Date:  1973-12       Impact factor: 3.765

9.  Viscoelastic stress/strain behavior of pharmaceutical tablets: analysis during unloading and postcompression periods.

Authors:  E G Rippie; D W Danielson
Journal:  J Pharm Sci       Date:  1981-05       Impact factor: 3.534

10.  Compression characteristics of some pharmaceutical materials.

Authors:  S Leigh; J E Carless; B W Burt
Journal:  J Pharm Sci       Date:  1967-07       Impact factor: 3.534

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  1 in total

Review 1.  Unraveling the Interaction between FcRn and Albumin: Opportunities for Design of Albumin-Based Therapeutics.

Authors:  Kine Marita Knudsen Sand; Malin Bern; Jeannette Nilsen; Hanna Theodora Noordzij; Inger Sandlie; Jan Terje Andersen
Journal:  Front Immunol       Date:  2015-01-26       Impact factor: 7.561

  1 in total

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