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Literature DB >> 9325064

IL-6: insights into novel biological activities.

Abstract

IL-6 has many novel activities both within the adaptive immune system and without. It has therapeutic potential in acute inflammation, such as toxic or septic shock, and it is a potential target for cachexia, multiple myeloma, and osteoporosis. Further work on these aspects of IL-6 biology should yield new insight into the possibility of IL-6 both as a therapeutic agent and as a target for antagonists.

Entities: Disease Gene

Mesh：

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Year: 1997 PMID： 9325064 DOI： 10.1006/clin.1997.4420

Source DB: PubMed Journal: Clin Immunol Immunopathol ISSN： 0090-1229

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Cited

52 in total

1. CD44 deficiency leads to enhanced neutrophil migration and lung injury in Escherichia coli pneumonia in mice.

Authors: Qin Wang; Priit Teder; Nancy P Judd; Paul W Noble; Claire M Doerschuk
Journal: Am J Pathol Date: 2002-12 Impact factor: 4.307

2. Neutralizing IL-6 reduces human arterial allograft rejection by allowing emergence of CD161+ CD4+ regulatory T cells.

Authors: Birgit Fogal; Tai Yi; Chen Wang; Deepak A Rao; Amir Lebastchi; Sanjay Kulkarni; George Tellides; Jordan S Pober
Journal: J Immunol Date: 2011-11-14 Impact factor: 5.422

3. Dose-rate effects of protons on in vivo activation of nuclear factor-kappa B and cytokines in mouse bone marrow cells.

Authors: Kanokporn Noy Rithidech; Paiboon Reungpatthanaphong; Louise Honikel; Adam Rusek; Sanford R Simon
Journal: Radiat Environ Biophys Date: 2010-05-28 Impact factor: 1.925

Review 4. Social support and health: a review of physiological processes potentially underlying links to disease outcomes.

Authors: Bert N Uchino
Journal: J Behav Med Date: 2006-06-07

5. Immune responses in tuberculosis: antibodies and CD4-CD8 lymphocytes with vascular adhesion molecules and cytokines (chemokines) cause a rapid antigen-specific cell infiltration at sites of bacillus Calmette-Guérin reinfection.

Authors: T Shigenaga; A M Dannenberg; D B Lowrie; W Said; M J Urist; H Abbey; B H Schofield; P Mounts; K Sugisaki
Journal: Immunology Date: 2001-04 Impact factor: 7.397

6. Hypoxia-increased expression of genes involved in inflammation, dedifferentiation, pro-fibrosis, and extracellular matrix remodeling of human bladder smooth muscle cells.

Authors: Bridget Wiafe; Adetola Adesida; Thomas Churchill; Esther Ekpe Adewuyi; Zack Li; Peter Metcalfe
Journal: In Vitro Cell Dev Biol Anim Date: 2016-09-08 Impact factor: 2.416

IL-6: insights into novel biological activities.

1. CD44 deficiency leads to enhanced neutrophil migration and lung injury in Escherichia coli pneumonia in mice.

2. Neutralizing IL-6 reduces human arterial allograft rejection by allowing emergence of CD161+ CD4+ regulatory T cells.

3. Dose-rate effects of protons on in vivo activation of nuclear factor-kappa B and cytokines in mouse bone marrow cells.

Review 4. Social support and health: a review of physiological processes potentially underlying links to disease outcomes.

5. Immune responses in tuberculosis: antibodies and CD4-CD8 lymphocytes with vascular adhesion molecules and cytokines (chemokines) cause a rapid antigen-specific cell infiltration at sites of bacillus Calmette-Guérin reinfection.

6. Hypoxia-increased expression of genes involved in inflammation, dedifferentiation, pro-fibrosis, and extracellular matrix remodeling of human bladder smooth muscle cells.

7. Local effects of recombinant rat interleukin-6 on the peripheral nervous system.

Review 8. Cytokine regulation of epithelial permeability and ion transport.

9. Corticotropin-releasing hormone regulates IL-6 expression during inflammation.

Review 10. Integration of cytokine biology and lipid metabolism in stroke.