Literature DB >> 9324630

[Cytokines and heart diseases. Attempt at an update].

K Werdan1.   

Abstract

UNLABELLED: Acute septic cardiomyopathy is-to our present knowledge-the heart disease most strongly interrelated with cytokines. Myocardial depression by cytokines is characterized by their pleiotropic actions mediating not only impairment of one, but several inotropic cascades. Information concerning the relevance of cytokines in non-septic heart diseases is-at present-scarce: Concepts emerge in cases of myocarditis, heart failure and cardiomyopathies, acute coronary syndromes, systemic inflammatory response due to cardiopulmonary bypass, heart transplant rejection and Kawasaki disease.
CONCLUSION: Cytokines are involved in heart diseases.

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Year:  1997        PMID： 9324630     DOI： 10.1007/BF03042576

Source DB:  PubMed          Journal:  Med Klin (Munich)        ISSN： 0723-5003


  20 in total

1.  Tumor necrosis factor alpha up-regulates Gi alpha and G beta proteins and adenylyl cyclase responsiveness in rat cardiomyocytes.

Authors:  C Reithmann; P Gierschik; K Werdan; K H Jakobs
Journal:  Eur J Pharmacol       Date:  1991-01-25       Impact factor: 4.432

Review 2.  [Acute septic cardiomyopathy: a manifestation in multi-organ failure in infection?].

Authors:  K Werdan; P Boekstegers; U Müller; A Pfeifer; G Pilz; C Reithmann; S Hallström; B Koidl; H P Schuster; G Schlag
Journal:  Med Klin (Munich)       Date:  1991-10-15

Review 3.  [The heart in infection and MODS (multiple organ dysfunction syndrome)].

Authors:  U Müller-Werdan; R Prondzinsky; R Witthaut; N Stache; K Heinroth; C Kuhn; H Schmidt; I Busch; K Werdan
Journal:  Wien Klin Wochenschr       Date:  1997       Impact factor: 1.704

4.  Elevated circulating tumor necrosis factor-alpha in patients with Kawasaki disease.

Authors:  C P Maury; E Salo; P Pelkonen
Journal:  J Lab Clin Med       Date:  1989-05

5.  Subchronic exposure of cardiomyocytes to low concentrations of tumor necrosis factor alpha attenuates the positive inotropic response not only to catecholamines but also to cardiac glycosides and high calcium concentrations.

Authors:  P Boekstegers; I Kainz; W Giehrl; W Peter; K Werdan
Journal:  Mol Cell Biochem       Date:  1996-03-23       Impact factor: 3.396

6.  High plasma tumor necrosis factor (TNF)-alpha concentrations and a sepsis-like syndrome in patients undergoing hyperthermic isolated limb perfusion with recombinant TNF-alpha, interferon-gamma, and melphalan.

Authors:  J H Zwaveling; J K Maring; F L Clarke; R J van Ginkel; P C Limburg; H J Hoekstra; H S Koops; A R Girbes
Journal:  Crit Care Med       Date:  1996-05       Impact factor: 7.598

Review 7.  Cytokine responses to cardiopulmonary bypass: lessons learned from cardiac transplantation.

Authors:  S Wan; J L LeClerc; J L Vincent
Journal:  Ann Thorac Surg       Date:  1997-01       Impact factor: 4.330

Review 8.  Elucidating molecular mechanisms of septic cardiomyopathy--the cardiomyocyte model.

Authors:  K Werdan; U Müller-Werdan
Journal:  Mol Cell Biochem       Date:  1996 Oct-Nov       Impact factor: 3.842

9.  Tumor necrosis factor alpha decreases inositol phosphate formation and phosphatidylinositol-bisphosphate (PIP2) synthesis in rat cardiomyocytes.

Authors:  C Reithmann; K Werdan
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1994-02       Impact factor: 3.000

10.  Pseudomonas sepsis does not cause more severe cardiovascular dysfunction in patients than non-Pseudomonas sepsis.

Authors:  G Pilz; P McGinn; P Boekstegers; S Kääb; S Weidenhöfer; K Werdan
Journal:  Circ Shock       Date:  1994-04
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