Literature DB >> 9324091

Corticosteroid effects in skeletal muscle: gene induction/receptor autoregulation.

L I McKay1, D C DuBois, Y N Sun, R R Almon, W J Jusko.   

Abstract

Common side effects of corticosteroid therapy include muscle weakness and atrophy, which are in part mediated by the induction of the enzyme glutamine synthetase. In addition, corticosteroids autoregulate their own receptor, thereby modulating tissue sensitivity to the hormone. The data in this report demonstrate that these gene-mediated effects are evident in muscle after short-term administration. Determination of molecular response dynamics could be useful in the design of future treatment regimens.

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Year:  1997        PMID： 9324091     DOI： 10.1002/(sici)1097-4598(199710)20:10<1318::aid-mus17>3.0.co;2-z

Source DB:  PubMed          Journal:  Muscle Nerve        ISSN： 0148-639X            Impact factor:   3.217


  10 in total

1.  The genomic response of skeletal muscle to methylprednisolone using microarrays: tailoring data mining to the structure of the pharmacogenomic time series.

Authors:  Richard R Almon; Debra C DuBois; William H Piel; William J Jusko
Journal:  Pharmacogenomics       Date:  2004-07       Impact factor: 2.533

2.  Pharmacogenomic responses of rat liver to methylprednisolone: an approach to mining a rich microarray time series.

Authors:  Richard R Almon; Debra C Dubois; Jin Y Jin; William J Jusko
Journal:  AAPS J       Date:  2005-08-18       Impact factor: 4.009

3.  Corticosteroid-regulated genes in rat kidney: mining time series array data.

Authors:  Richard R Almon; William Lai; Debra C DuBois; William J Jusko
Journal:  Am J Physiol Endocrinol Metab       Date:  2005-06-28       Impact factor: 4.310

4.  Mathematical assessment of properties of precursor-dependent indirect pharmacodynamic response models.

Authors:  Anasuya Hazra; Wojciech Krzyzanski; William J Jusko
Journal:  J Pharmacokinet Pharmacodyn       Date:  2006-10-12       Impact factor: 2.745

Review 5.  Applications of quantitative pharmacodynamic effect markers in drug target identification and therapy development.

Authors:  Robert M Straubinger; Wojciech Krzyzanski; Crystal M Francoforte; Jun Qu
Journal:  Anticancer Res       Date:  2007 May-Jun       Impact factor: 2.480

6.  Relationships between circadian rhythms and modulation of gene expression by glucocorticoids in skeletal muscle.

Authors:  Richard R Almon; Eric Yang; William Lai; Ioannis P Androulakis; Svetlana Ghimbovschi; Eric P Hoffman; William J Jusko; Debra C Dubois
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2008-07-30       Impact factor: 3.619

7.  Estrogen (17beta-estradiol) enhances glutamine synthetase activity in C6-glioma cells.

Authors:  N Haghighat
Journal:  Neurochem Res       Date:  2005-05       Impact factor: 3.996

8.  A microarray analysis of the temporal response of liver to methylprednisolone: a comparative analysis of two dosing regimens.

Authors:  Richard R Almon; Debra C DuBois; William J Jusko
Journal:  Endocrinology       Date:  2007-02-15       Impact factor: 4.736

9.  Dose-dependence and repeated-dose studies for receptor/gene-mediated pharmacodynamics of methylprednisolone on glucocorticoid receptor down-regulation and tyrosine aminotransferase induction in rat liver.

Authors:  Y N Sun; D C DuBois; R R Almon; N A Pyszczynski; W J Jusko
Journal:  J Pharmacokinet Biopharm       Date:  1998-12

10.  Microarray analysis of the temporal response of skeletal muscle to methylprednisolone: comparative analysis of two dosing regimens.

Authors:  Richard R Almon; Debra C DuBois; Zhenling Yao; Eric P Hoffman; Svetlana Ghimbovschi; William J Jusko
Journal:  Physiol Genomics       Date:  2007-05-01       Impact factor: 3.107
  10 in total

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