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Literature DB >> 9323512

IL-10 production in multiple sclerosis patients, SLE patients and healthy controls: preliminary findings.

M Gelati¹, E Lamperti, A Dufour, E Corsini, E Venegoni, C Milanese, A Nespolo, A Salmaggi.

Abstract

IL-10 is a cytokine with suppressive effects on (auto) antigen presentation and T-cell-mediated immune reactions, but is also capable of stimulating polyclonal IgG synthesis. Recent evidence suggests its involvement in multiple sclerosis (MS) and systemic lupus erythematosus (SLE). We assessed PBMNC IL-10 release in MS and SLE patients before and after in vivo prednisone or methylprednisolone treatment. The SLE patients showed a high level of IL-10 release by unstimulated PBMNCs, whereas the PHA-stimulated PBMNCs from MS patients produced large amounts of the cytokine.

Entities: Chemical Disease Gene Species

Mesh：

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Year: 1997 PMID： 9323512 DOI： 10.1007/BF02080463

Source DB: PubMed Journal: Ital J Neurol Sci ISSN： 0392-0461

11 in total

1. Serum interleukin 10 titers in systemic lupus erythematosus reflect disease activity.

Authors: F A Houssiau; C Lefebvre; M Vanden Berghe; M Lambert; J P Devogelaer; J C Renauld
Journal: Lupus Date: 1995-10 Impact factor: 2.911

2. Correlation of T and B cell activities in vitro and serum IL-2 levels in systemic lupus erythematosus.

Authors: Y P Huang; L H Perrin; P A Miescher; R H Zubler
Journal: J Immunol Date: 1988-08-01 Impact factor: 5.422

3. Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes.

Authors: F Rousset; E Garcia; T Defrance; C Péronne; N Vezzio; D H Hsu; R Kastelein; K W Moore; J Banchereau
Journal: Proc Natl Acad Sci U S A Date: 1992-03-01 Impact factor: 11.205

4. IL-10 inhibits cytokine production by activated macrophages.

Authors: D F Fiorentino; A Zlotnik; T R Mosmann; M Howard; A O'Garra
Journal: J Immunol Date: 1991-12-01 Impact factor: 5.422

5. Alterations in peripheral blood mononuclear cell cytokine production in response to phytohemagglutinin in multiple sclerosis patients.

Authors: B Crucian; P Dunne; H Friedman; R Ragsdale; S Pross; R Widen
Journal: Clin Diagn Lab Immunol Date: 1995-11

6. Intrathecal synthesis of interleukin-10 (IL-10) in viral and inflammatory diseases of the central nervous system.

Authors: P Gallo; S Sivieri; L Rinaldi; X B Yan; F Lolli; A De Rossi; B Tavolato
Journal: J Neurol Sci Date: 1994-10 Impact factor: 3.181

7. In vivo production of interleukin-10 by non-T cells in rheumatoid arthritis, Sjögren's syndrome, and systemic lupus erythematosus. A potential mechanism of B lymphocyte hyperactivity and autoimmunity.

Authors: L Llorente; Y Richaud-Patin; R Fior; J Alcocer-Varela; J Wijdenes; B M Fourrier; P Galanaud; D Emilie
Journal: Arthritis Rheum Date: 1994-11

8. Interleukin-10 prevents experimental allergic encephalomyelitis in rats.

Authors: O Rott; B Fleischer; E Cash
Journal: Eur J Immunol Date: 1994-06 Impact factor: 5.532

9. Characterization of T lymphocyte subpopulations responsible for deficient interleukin 2 activity in patients with systemic lupus erythematosus.

Authors: Y Murakawa; S Takada; Y Ueda; N Suzuki; T Hoshino; T Sakane
Journal: J Immunol Date: 1985-01 Impact factor: 5.422

10. Role of interleukin 10 in the B lymphocyte hyperactivity and autoantibody production of human systemic lupus erythematosus.

Authors: L Llorente; W Zou; Y Levy; Y Richaud-Patin; J Wijdenes; J Alcocer-Varela; B Morel-Fourrier; J C Brouet; D Alarcon-Segovia; P Galanaud; D Emilie
Journal: J Exp Med Date: 1995-03-01 Impact factor: 14.307

3 in total