| Literature DB >> 9323305 |
G K Matheson1, A Knowles, D Gage, C Michel, D Guthrie, C Bauer, J Blackbourne, D Weinzapfel.
Abstract
The effects of tandospirone, enciprazine, gepirone, buspirone (5-HT1A agents) and carvotroline (5-HT2) on hypothalamic-pituitary-adrenocortical activity (HPA) activity were studied. These drugs increased the plasma corticosterone levels in a dose-dependent manner. Their ED50 values were 3.8, 31.8, 3.1, 3.4 and 7.0 mg/kg, respectively. Drug effects peaked between 30 min and 1 h, and plasma corticosterone levels returned to control levels after 2 h. When the drugs were given in conjunction with a rotatory stress, gepirone and enciprazine increased and carvotroline decreased plasma corticosterone levels. Dexamethasone (0.1 mg/kg) pretreatment reduced drug-activated HPA axis activity.Entities:
Mesh：
Substances：
Year: 1997 PMID： 9323305 DOI： 10.1159/000139513
Source DB: PubMed Journal: Pharmacology ISSN： 0031-7012 Impact factor: 2.547