Literature DB >> 9322362

Study on cytotoxic oxygenated desmosterols isolated from the red alga Galaxaura marginata.

J H Sheu1, S Y Huang, G H Wang, C Y Duh.   

Abstract

Four novel oxygenated desmosterols, 24 zeta-hydroperoxy-6 beta-hydroxycholesta-4,25-dien-3-one (1), 25-hydroperoxy-6 beta-hydroxycholesta-4,23(E)-dien-3-one (2), 24 zeta-hydroperoxycholesta-4,25-diene-3,6-dione (3), and 25-hydroperoxycholesta-4,23(E)-diene-3,6-dione (4) were isolated from the marine red alga Galaxaura marginata. Steroids 1-4 and three synthetic oxygenated desmosterols 5-7 were shown to exhibit significant cytotoxicity against several cancer cell lines.

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Year:  1997        PMID： 9322362     DOI： 10.1021/np9701844

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  6 in total

1.  Acute toxicity study and antipyretic effect of the brown alga Turbinaria conoides (J. Agardh) Kuetz.

Authors:  S Sadish Kumar; Y Kumar; M S Y Khan; J Anbu; K G Sam
Journal:  Afr J Tradit Complement Altern Med       Date:  2009-05-07

2.  Antimicrobial and cytotoxic activities of turbinariaconoides (j.agardh) kuetz.

Authors:  Sadish Kumar Shanmugam; Yatendra Kumar; Khan Mohammad Sardaryar; Vivek Gupta; Erik De Clercq
Journal:  Iran J Pharm Res       Date:  2010       Impact factor: 1.696

3.  Bioactive chemical constituents from the brown alga Homoeostrichus formosana.

Authors:  Hui-Yu Fang; Uvarani Chokkalingam; Shu-Fen Chiou; Tsong-Long Hwang; Shu-Li Chen; Wei-Lung Wang; Jyh-Horng Sheu
Journal:  Int J Mol Sci       Date:  2014-12-30       Impact factor: 5.923

4.  A Structure- and Ligand-Based Virtual Screening of a Database of "Small" Marine Natural Products for the Identification of "Blue" Sigma-2 Receptor Ligands.

Authors:  Giuseppe Floresta; Emanuele Amata; Carla Barbaraci; Davide Gentile; Rita Turnaturi; Agostino Marrazzo; Antonio Rescifina
Journal:  Mar Drugs       Date:  2018-10-14       Impact factor: 5.118

5.  Linking Ayurveda and Western medicine by integrative analysis.

Authors:  Fazlin Mohd Fauzi; Alexios Koutsoukas; Robert Lowe; Kalpana Joshi; Tai-Ping Fan; Robert C Glen; Andreas Bender
Journal:  J Ayurveda Integr Med       Date:  2013-04

6.  An In silico Based Comparison of Drug Interactions in Wild and Mutant Human β-tubulin through Docking Studies.

Authors:  Selvaakumar Chellasamy; Sudheer M M Mohammed
Journal:  Avicenna J Med Biotechnol       Date:  2014-04
  6 in total

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