Pediatric nosocomial fungal infections.

During a period of twelve years (1984-1995), ninety-seven pediatric patients experienced 107 nosocomial fungal infections at Mackay Memorial Hospital. The nosocomial fungal infection rate in pediatric patients was lower than that of the hospital as whole, but it increased significantly. The average rate in the last three years (1993-1995) was 1.20 per thousand discharged patients, 10 times that of the first three years (1984-1986). Two-thirds of the patients were below one year of age. Half of the infections occurred in Intensive Care Units. The bloodstream was the most common site of infection (40.2%), followed by the urinary tract and skin. Important underlying diseases included malignancies, prematurity, and congenital anomalies. Common risk procedures included total parenteral nutrition (43.3%), endotracheal intubation (29.9%), central venous catheterization (25.8%), operation (14.4%). Near 90% of the patients had previously received antibiotics. Candida albicans was responsible for 58.1% of the infections. Thirty-three patients expired, of whom 18 died of the fungal infections. With the trend of increasing nosocomial fungal infections, physicians should be more alert to the possibility of such infections.