Literature DB >> 931886

Measurement of brain oxygen utilization with radioactive oxygen-15: experimental verification.

M E Raichle, R L Grubb, J O Eichling, M M Ter-Pogossian.   

Abstract

This study was designed to provide direct experimental evidence in support of the method employing radioactive 15O-tagged hemoglobin for the in vivo and regional measurement of the cerebral oxygen utilization rate (CMRO2). This was accomplished by simultaneously measuring in vivo the mean CMRO2 in monkeys and human beings by the 15O method and a direct appeal to the Fick principle using measured arteriovenous oxygen differences of brain. The correlation between the 2 methods was excellent, with a correlation coefficient of 0.90 (P less than 0.001) in monkeys and 0.88 (P less than 0.001) in human beings.

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Year:  1976        PMID： 931886     DOI： 10.1152/jappl.1976.40.4.638

Source DB:  PubMed          Journal:  J Appl Physiol        ISSN： 0021-8987            Impact factor:   3.531


  7 in total

Review 1.  The neural basis of the blood-oxygen-level-dependent functional magnetic resonance imaging signal.

Authors:  Nikos K Logothetis
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2002-08-29       Impact factor: 6.237

2.  Exploring new frontiers in molecular imaging: Emergence of Ga PET/CT.

Authors:  Eik Hock Tan; Soon Whatt Goh
Journal:  World J Radiol       Date:  2010-02-28

3.  The effect of acetazolamide on cerebral blood flow and oxygen utilization in the rhesus monkey.

Authors:  B E Laux; M E Raichle
Journal:  J Clin Invest       Date:  1978-09       Impact factor: 14.808

4.  Nonlinear model for capillary-tissue oxygen transport and metabolism.

Authors:  Z Li; T Yipintsoi; J B Bassingthwaighte
Journal:  Ann Biomed Eng       Date:  1997 Jul-Aug       Impact factor: 3.934

5.  Validation of oxygen extraction fraction measurement by qBOLD technique.

Authors:  Xiang He; Mingming Zhu; Dmitriy A Yablonskiy
Journal:  Magn Reson Med       Date:  2008-10       Impact factor: 4.668

6.  Cerebral blood volume, blood flow, and oxygen metabolism in cerebral ischaemia and subarachnoid haemorrhage: an in-vivo study using positron emission tomography.

Authors:  W R Martin; R P Baker; R L Grubb; M E Raichle
Journal:  Acta Neurochir (Wien)       Date:  1984       Impact factor: 2.216

7.  Adequacy of a compartment model for CMRO₂ quantitation using ¹⁵O-labeled oxygen and PET: a clearance measurement of ¹⁵O-radioactivity following intracarotid bolus injection of ¹⁵O-labeled oxyhemoglobin on Macaca fascicularis.

Authors:  Hidehiro Iida; Satoshi Iguchi; Noboru Teramoto; Kazuhiro Koshino; Tsutomu Zeniya; Akihide Yamamoto; Nobuyuki Kudomi; Tetsuaki Moriguchi; Yuki Hori; Junichiro Enmi; Hidekazu Kawashima; Nadim Joni Shah; Jyoji Nakagawara
Journal:  J Cereb Blood Flow Metab       Date:  2014-07-09       Impact factor: 6.200
  7 in total

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