A Emad1, G R Rezaian. 1. Department of Internal Medicine, Shiraz University of Medical Sciences, Iran.
Abstract
OBJECTIVE: To find out the late pulmonary sequelae of sulfur mustard gas inhalation in 197 veterans, 10 years after their exposure. DESIGN: Cross-sectional clinical study. SETTING: University hospital. PATIENTS: One hundred ninety-seven veterans with a single, heavy exposure to sulfur mustard gas in 1986 and 86 nonexposed veterans as their control group. INTERVENTIONS: Pulmonary function tests, carbon monoxide diffusion capacity, bronchoscopy, and high-resolution CT of the chest were performed in all patients. Transbronchial lung biopsy was done in 24 suspected cases of pulmonary fibrosis. RESULTS: Asthma was diagnosed in 21 (10.65%), chronic bronchitis in 116 (58.88%), bronchiectasis in 17 (8.62%), airway narrowing due to searing or granulation tissue in 19 (9.64%), and pulmonary fibrosis in 24 (12.18%) cases. None of these were found among the control group except for a single case of chronic bronchitis. CONCLUSION: Although the respiratory symptoms of an acute sulfur mustard gas inhalation are usually transient and nonspecific, it can lead to the development of a series of chronic destructive pulmonary sequelae in such cases.
OBJECTIVE: To find out the late pulmonary sequelae of sulfur mustard gas inhalation in 197 veterans, 10 years after their exposure. DESIGN: Cross-sectional clinical study. SETTING: University hospital. PATIENTS: One hundred ninety-seven veterans with a single, heavy exposure to sulfur mustard gas in 1986 and 86 nonexposed veterans as their control group. INTERVENTIONS: Pulmonary function tests, carbon monoxide diffusion capacity, bronchoscopy, and high-resolution CT of the chest were performed in all patients. Transbronchial lung biopsy was done in 24 suspected cases of pulmonary fibrosis. RESULTS: Asthma was diagnosed in 21 (10.65%), chronic bronchitis in 116 (58.88%), bronchiectasis in 17 (8.62%), airway narrowing due to searing or granulation tissue in 19 (9.64%), and pulmonary fibrosis in 24 (12.18%) cases. None of these were found among the control group except for a single case of chronic bronchitis. CONCLUSION: Although the respiratory symptoms of an acute sulfur mustard gas inhalation are usually transient and nonspecific, it can lead to the development of a series of chronic destructive pulmonary sequelae in such cases.
Authors: Matthew D McGraw; Marilyn M Dysart; Tara B Hendry-Hofer; Paul R Houin; Jaqueline S Rioux; Rhonda B Garlick; Joan E Loader; Russell Smith; Danielle C Paradiso; Wesley W Holmes; Dana R Anderson; Carl W White; Livia A Veress Journal: Am J Respir Cell Mol Biol Date: 2018-06 Impact factor: 6.914
Authors: Heidi C O'Neill; David J Orlicky; Tara B Hendry-Hofer; Joan E Loader; Brian J Day; Carl W White Journal: Am J Respir Cell Mol Biol Date: 2011-06-03 Impact factor: 6.914
Authors: Waylon M Weber; Dean A Kracko; Mericka R Lehman; Clinton M Irvin; Lee F Blair; Richard K White; Janet M Benson; Gary R Grotendorst; Yung-Sung Cheng; Jacob D McDonald Journal: Toxicol Mech Methods Date: 2010-01 Impact factor: 2.987