Literature DB >> 9315743

Urokinase plasminogen activator induces smooth muscle cell migration: key role of growth factor-like domain.

V Stepanova1, A Bobik, R Bibilashvily, A Belogurov, I Rybalkin, S Domogatsky, P J Little, E Goncharova, V Tkachuk.   

Abstract

We defined the role of urokinase plasminogen activator (uPA) and its growth factor-like domain (GFD) in stimulating smooth muscle cell (SMC) migration. Recombinant uPA (r-uPA) stimulated migration approximately 3-fold whilst the recombinant uPA mutant containing an altered GFD (r-uPAmut) was ineffective. Both uPA variants bound to the same high affinity receptor in a competitive manner. FGF-2- and PDGF-BB-induced migration was also dependent on uPA, their effects being antagonized by addition of a uPA-neutralizing antibody or the r-uPAmut. Thus r-uPA is chemotactic for SMC and stimulation of cell migration by PDGF-BB and FGF-2 is dependent on uPA. The GFD of uPA is essential for its chemotactic effects.

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Year:  1997        PMID： 9315743     DOI： 10.1016/s0014-5793(97)00993-9

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  10 in total

1.  Fibulin-5 binds urokinase-type plasminogen activator and mediates urokinase-stimulated β1-integrin-dependent cell migration.

Authors:  Alexander Kapustin; Victoria Stepanova; Natalia Aniol; Douglas B Cines; Alexei Poliakov; Serge Yarovoi; Tatiana Lebedeva; Robin Wait; Grigory Ryzhakov; Yelena Parfyonova; Yaroslav Gursky; Hiromi Yanagisawa; Mikhail Minashkin; Robert Beabealashvilli; Alexander Vorotnikov; Alex Bobik; Vsevolod Tkachuk
Journal:  Biochem J       Date:  2012-04-15       Impact factor: 3.857

2.  Urokinase plasminogen activator induces human smooth muscle cell migration and proliferation via distinct receptor-dependent and proteolysis-dependent mechanisms.

Authors:  V Stepanova; S Mukhina; E Köhler; T J Resink; P Erne; V A Tkachuk
Journal:  Mol Cell Biochem       Date:  1999-05       Impact factor: 3.396

3.  Inhibited proliferation of human umbilical artery smooth muscle cells by xanthinol nicotinate.

Authors:  Xiaodan Bai; Lijun Huang; Kejie Hu; Fujun Qu
Journal:  Med Biol Eng Comput       Date:  2015-12-30       Impact factor: 2.602

4.  Urokinase-induced signaling in human vascular smooth muscle cells is mediated by PDGFR-beta.

Authors:  Julia Kiyan; Roman Kiyan; Hermann Haller; Inna Dumler
Journal:  EMBO J       Date:  2005-05-05       Impact factor: 11.598

5.  Remodeling of the vessel wall after copper-induced injury is highly attenuated in mice with a total deficiency of plasminogen activator inhibitor-1.

Authors:  V A Ploplis; I Cornelissen; M J Sandoval-Cooper; L Weeks; F A Noria; F J Castellino
Journal:  Am J Pathol       Date:  2001-01       Impact factor: 4.307

6.  Mechanisms of kringle fragment of urokinase-induced vascular smooth muscle cell migration.

Authors:  Elisa Roztocil; Suzanne M Nicholl; Mark G Davies
Journal:  J Surg Res       Date:  2007-07       Impact factor: 2.192

7.  Protease-mediated human smooth muscle cell proliferation by urokinase requires epidermal growth factor receptor transactivation by triple membrane signaling.

Authors:  Enrico A Duru; Yuyang Fu; Mark G Davies
Journal:  J Surg Res       Date:  2014-07-02       Impact factor: 2.192

8.  Urokinase upregulates matrix metalloproteinase-9 expression in THP-1 monocytes via gene transcription and protein synthesis.

Authors:  Mikhail Menshikov; Eugenia Elizarova; Karina Plakida; Angelika Timofeeva; Georgy Khaspekov; Robert Beabealashvilli; Alex Bobik; Vsevolod Tkachuk
Journal:  Biochem J       Date:  2002-11-01       Impact factor: 3.857

9.  Urokinase-type plasminogen activator receptor interaction with β1 integrin is required for platelet-derived growth factor-AB-induced human mesenchymal stem/stromal cell migration.

Authors:  Valérie Chabot; Cécile Dromard; Angélique Rico; Alain Langonné; Julien Gaillard; Fabien Guilloton; Louis Casteilla; Luc Sensebé
Journal:  Stem Cell Res Ther       Date:  2015-09-29       Impact factor: 6.832

10.  Downregulation of urokinase plasminogen activator receptor expression inhibits Erk signalling with concomitant suppression of invasiveness due to loss of uPAR-beta1 integrin complex in colon cancer cells.

Authors:  N Ahmed; K Oliva; Y Wang; M Quinn; G Rice
Journal:  Br J Cancer       Date:  2003-07-21       Impact factor: 7.640
  10 in total

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