| Literature DB >> 9315107 |
D M See1, P Khemka, L Sahl, T Bui, J G Tilles.
Abstract
Natural killer (NK) cells are important effectors for the lysis of both neoplastic and virus-infected cells. Lectin-like receptors on human NK cells, such as NKR-PIA and CD94, bind to target cell carbohydrate ligands and initiate the lytic process. In addition, P58 and P70 bind to major histocompatibility class I antigens on targets and mediate negative signals. Models using NK cell-deficient mice have proven useful in elaborating the role of NK cells in the immune defence against multiple viral agents. In addition, studies in humans have suggested a vital role of NK cells in the host defence against human immunodeficiency virus, herpesviruses, hepatitis B and C and other viruses. Several genetic disorders, chronic illnesses and infections have been associated with decreased NK function.Entities:
Mesh:
Substances:
Year: 1997 PMID: 9315107 DOI: 10.1046/j.1365-3083.1997.d01-121.x
Source DB: PubMed Journal: Scand J Immunol ISSN: 0300-9475 Impact factor: 3.487