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Literature DB >> 9315080

Borrelidin is an angiogenesis inhibitor; disruption of angiogenic capillary vessels in a rat aorta matrix culture model.

T Wakabayashi¹, R Kageyama, N Naruse, N Tsukahara, Y Funahashi, K Kitoh, Y Watanabe.

Abstract

Borrelidin, an antibiotic from Streptomyces rochei, was found to be an angiogenesis inhibitor in a rat aorta matrix culture model which forms capillary vessels in vitro. Borrelidin strongly inhibited capillary tube formation with a 50%-inhibitory concentration value of 0.8 nM, and decreased the number of capillary tubes within 24 hours when added after maturation of tube formation. Borrelidin remarkably disrupted capillary tubes in a dose-dependent manner, by inducing apoptosis of the tube-forming cells.

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Year: 1997 PMID： 9315080 DOI： 10.7164/antibiotics.50.671

Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649

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Cited

11 in total

Review 1. Progress and challenges in aminoacyl-tRNA synthetase-based therapeutics.

Authors: Christopher S Francklyn; Patrick Mullen
Journal: J Biol Chem Date: 2019-01-22 Impact factor: 5.157

2. Liposomal borrelidin for treatment of metastatic breast cancer.

Authors: Moonkyoung Jeong; Heegon Kim; Sunghoon Kim; Ji-Ho Park
Journal: Drug Deliv Transl Res Date: 2018-10 Impact factor: 4.617

3. Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.

Authors: Alpa Sidhu; Justin R Miller; Ashootosh Tripathi; Danielle M Garshott; Amy L Brownell; Daniel J Chiego; Carl Arevang; Qinghua Zeng; Leah C Jackson; Shelby A Bechler; Michael U Callaghan; George H Yoo; Seema Sethi; Ho-Sheng Lin; Joseph H Callaghan; Giselle Tamayo-Castillo; David H Sherman; Randal J Kaufman; Andrew M Fribley
Journal: ACS Med Chem Lett Date: 2015-09-08 Impact factor: 4.345

4. Insights into the preclinical treatment of blood-stage malaria by the antibiotic borrelidin.

Authors: I G Azcárate; P Marín-García; N Camacho; S Pérez-Benavente; A Puyet; A Diez; L Ribas de Pouplana; J M Bautista
Journal: Br J Pharmacol Date: 2013-06 Impact factor: 8.739

5. Borrelidin modulates the alternative splicing of VEGF in favour of anti-angiogenic isoforms.

Authors: Jeanette Woolard; William Vousden; Steven J Moss; Arjun Krishnakumar; Melissa Vr Gammons; David G Nowak; Neil Dixon; Jason Micklefield; Astrid Spannhoff; Mark T Bedford; Matthew A Gregory; Christine J Martin; Peter F Leadlay; Ming Q Zhang; Steven J Harper; David O Bates; Barrie Wilkinson
Journal: Chem Sci Date: 2011-02-01 Impact factor: 9.825

Borrelidin is an angiogenesis inhibitor; disruption of angiogenic capillary vessels in a rat aorta matrix culture model.

Review 1. Progress and challenges in aminoacyl-tRNA synthetase-based therapeutics.

2. Liposomal borrelidin for treatment of metastatic breast cancer.

3. Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.

4. Insights into the preclinical treatment of blood-stage malaria by the antibiotic borrelidin.

5. Borrelidin modulates the alternative splicing of VEGF in favour of anti-angiogenic isoforms.

6. Aminoacyl-tRNA synthetase dependent angiogenesis revealed by a bioengineered macrolide inhibitor.

Review 7. Regulation of angiogenesis by aminoacyl-tRNA synthetases.

8. Structural basis for full-spectrum inhibition of translational functions on a tRNA synthetase.

Review 9. Alternative Splicing as a Target for Cancer Treatment.

10. Secreted Threonyl-tRNA synthetase stimulates endothelial cell migration and angiogenesis.