BACKGROUND: Neutropenic colitis is a clinicopathological syndrome characteristically seen as a complication of chemotherapy for haematological malignancy. This review explores the pathogenesis of the condition and appraises the options for management. METHODS: A Medline search was carried out and all relevant papers were reviewed. RESULTS: There are many case reports but few published series, so experience is mainly anecdotal. Both medical and surgical management have been successful; it is not possible to compare treatment groups formally. CONCLUSION: The greater use of aggressive multiagent chemotherapy regimens may increase the frequency with which the condition is encountered. Heightened awareness of neutropenic colitis may prompt diagnosis and a better understanding of the pathophysiology may help guide clinical management.
BACKGROUND:Neutropenic colitis is a clinicopathological syndrome characteristically seen as a complication of chemotherapy for haematological malignancy. This review explores the pathogenesis of the condition and appraises the options for management. METHODS: A Medline search was carried out and all relevant papers were reviewed. RESULTS: There are many case reports but few published series, so experience is mainly anecdotal. Both medical and surgical management have been successful; it is not possible to compare treatment groups formally. CONCLUSION: The greater use of aggressive multiagent chemotherapy regimens may increase the frequency with which the condition is encountered. Heightened awareness of neutropenic colitis may prompt diagnosis and a better understanding of the pathophysiology may help guide clinical management.
Authors: Andrés Felipe Cardona Zorrilla; Ludovic Reveiz Herault; Alexandra Casasbuenas; Diego Mauricio Aponte; Pedro Luis Ramos Journal: Clin Transl Oncol Date: 2006-01 Impact factor: 3.405
Authors: Marcus Gorschlüter; Ulrich Mey; John Strehl; Volker Schmitz; Christian Rabe; Katharina Pauls; Carsten Ziske; Ingo G H Schmidt-Wolf; Axel Glasmacher Journal: BMC Infect Dis Date: 2006-02-26 Impact factor: 3.090