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Literature DB >> 9311905

A role for two hairpin structures as a core RNA encapsidation signal in murine leukemia virus virions.

Abstract

Four putative hairpin structures (hairpins A to D) are involved in the specific encapsidation of Moloney murine leukemia virus (M-MuLV) RNA into M-MuLV virus particles. The C and D elements, encompassing M-MuLV viral nucleotides 310 to 374, facilitate encapsidation of heterologous RNA into virions. Thus, these two elements appear to act as a core RNA encapsidation signal. The loop sequences of the putative C and D hairpins are identical (GACG). However, when GACG loops were introduced into RNAs on heterologous stem sequences, they increased encapsidation levels only three- to fourfold. These results suggest that C and D stem-and-loop sequences contribute to the M-MuLV cis-acting site for encapsidation.

Entities: Disease

Mesh：

Substances：
RNA, Viral

Year: 1997 PMID： 9311905 PMCID： PMC192172 DOI： 10.1128/JVI.71.10.8061-8065.1997

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

30 in total

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33 in total

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Review 9. Virus maturation by budding.

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