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Literature DB >> 9311904

IE2 protein is insufficient for transcriptional repression of the human cytomegalovirus US3 promoter.

Abstract

Expression of the human cytomegalovirus (HCMV) US3 gene is regulated in part by transcriptional repression mediated through a cis-repressive region located between the TATA box and the transcriptional start site. The US3 cis-repressive element has extensive sequence identity with a similar repressive element in UL122-123 (the major immediate-early gene complex). Repression of UL122-123 is mediated through the interaction of the IE2 protein with cis-repressive sequences. In spite of the similarity of the two repressive elements, IE2 activated rather than repressed transcription from the US3 promoter. Additionally, IE1 or IE1 and IE2 in combination also activated US3 expression. These data demonstrate that regulation of HCMV immediate-early genes is quite complex and involves a number of proteins.

Entities: Gene Species

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Year: 1997 PMID： 9311904 PMCID： PMC192171 DOI： 10.1128/JVI.71.10.8056-8060.1997

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

25 in total

1. Sequence requirements for activation of the HIV-1 LTR by human cytomegalovirus.

Authors: B J Biegalke; A P Geballe
Journal: Virology Date: 1991-07 Impact factor: 3.616

2. A 15-kilobase-pair region of the human cytomegalovirus genome which includes US1 through US13 is dispensable for growth in cell culture.

Authors: A Kollert-Jöns; E Bogner; K Radsak
Journal: J Virol Date: 1991-10 Impact factor: 5.103

3. A cis-acting element in the major immediate-early (IE) promoter of human cytomegalovirus is required for negative regulation by IE2.

Authors: B Liu; T W Hermiston; M F Stinski
Journal: J Virol Date: 1991-02 Impact factor: 5.103

4. Enhancement of RNA polymerase II initiation complexes by a novel DNA control domain downstream from the cap site of the cytomegalovirus major immediate-early promoter.

Authors: P Ghazal; J A Nelson
Journal: J Virol Date: 1991-05 Impact factor: 5.103

Review 5. Analysis of the protein-coding content of the sequence of human cytomegalovirus strain AD169.

Authors: M S Chee; A T Bankier; S Beck; R Bohni; C M Brown; R Cerny; T Horsnell; C A Hutchison; T Kouzarides; J A Martignetti
Journal: Curr Top Microbiol Immunol Date: 1990 Impact factor: 4.291

6. Human cytomegalovirus US2 destabilizes major histocompatibility complex class I heavy chains.

Authors: T R Jones; L Sun
Journal: J Virol Date: 1997-04 Impact factor: 5.103

7. The IE2 gene products of human cytomegalovirus specifically down-regulate expression from the major immediate-early promoter through a target sequence located near the cap site.

Authors: M C Pizzorno; G S Hayward
Journal: J Virol Date: 1990-12 Impact factor: 5.103

8. Human cytomegalovirus immediate-early two protein region involved in negative regulation of the major immediate-early promoter.

Authors: T W Hermiston; C L Malone; M F Stinski
Journal: J Virol Date: 1990-07 Impact factor: 5.103

9. A specific subform of the human cytomegalovirus transactivator protein pUL69 is contained within the tegument of virus particles.

Authors: M Winkler; T Stamminger
Journal: J Virol Date: 1996-12 Impact factor: 5.103

10. Human cytomegalovirus ie2 negatively regulates alpha gene expression via a short target sequence near the transcription start site.

Authors: J M Cherrington; E L Khoury; E S Mocarski
Journal: J Virol Date: 1991-02 Impact factor: 5.103

6 in total

1. Identification of a novel element involved in regulation of the lytic switch BZLF1 gene promoter of Epstein-Barr virus.

Authors: R J Kraus; S J Mirocha; H M Stephany; J R Puchalski; J E Mertz
Journal: J Virol Date: 2001-01 Impact factor: 5.103

2. Two gamma interferon-activated site-like elements in the human cytomegalovirus major immediate-early promoter/enhancer are important for viral replication.

Authors: James Netterwald; Shaojun Yang; Weijia Wang; Salena Ghanny; Michael Cody; Patricia Soteropoulos; Bin Tian; Walter Dunn; Fenyong Liu; Hua Zhu
Journal: J Virol Date: 2005-04 Impact factor: 5.103

6. A cis repression sequence adjacent to the transcription start site of the human cytomegalovirus US3 gene is required to down regulate gene expression at early and late times after infection.

Authors: P E Lashmit; M F Stinski; E A Murphy; G C Bullock
Journal: J Virol Date: 1998-12 Impact factor: 5.103