Literature DB >> 9310241

Low frequency of allelic loss in skin tumours from immunosuppressed individuals.

I Rehman1, A G Quinn, M Takata, A E Taylor, J L Rees.   

Abstract

Organ transplant recipients receiving immunosuppression show a dramatically increased risk of non-melanoma skin cancer. The cause of this increase is not known. We report that the rate of loss of heterozygosity (at all the loci we examined) was significantly lower in tumours from immunosuppressed individuals than in tumours from immunocompetent subjects [20 out of 148 (14%) vs 157 out of 428 (37%); P< 0.0001]. These results suggest that tumours in immunosuppressed individuals have a different molecular pathogenesis.

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Year:  1997        PMID： 9310241      PMCID： PMC2228045          DOI： 10.1038/bjc.1997.457

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  16 in total

1.  Papillomaviruses, p53, and cervical cancer.

Authors:  R M Busby-Earle; C M Steel; A R Williams; B Cohen; C C Bird
Journal:  Lancet       Date:  1992-05-30       Impact factor: 79.321

2.  p53 point mutation in HPV negative human cervical carcinoma cell lines.

Authors:  T Crook; D Wrede; K H Vousden
Journal:  Oncogene       Date:  1991-05       Impact factor: 9.867

3.  Genetic change in actinic keratoses.

Authors:  I Rehman; M Takata; Y Y Wu; J L Rees
Journal:  Oncogene       Date:  1996-06-20       Impact factor: 9.867

Review 4.  Lessons from hereditary colorectal cancer.

Authors:  K W Kinzler; B Vogelstein
Journal:  Cell       Date:  1996-10-18       Impact factor: 41.582

5.  Incidence of skin cancer after renal transplantation in The Netherlands.

Authors:  M M Hartevelt; J N Bavinck; A M Kootte; B J Vermeer; J P Vandenbroucke
Journal:  Transplantation       Date:  1990-03       Impact factor: 4.939

Review 6.  Cutaneous manifestations of immunosuppression in organ transplant recipients.

Authors:  E A Abel
Journal:  J Am Acad Dermatol       Date:  1989-08       Impact factor: 11.527

7.  Human papilloma virus infection and skin cancer in renal allograft recipients.

Authors:  B B Barr; E C Benton; K McLaren; M H Bunney; I W Smith; K Blessing; J A Hunter
Journal:  Lancet       Date:  1989-01-21       Impact factor: 79.321

Review 8.  Interactions of human papillomavirus transforming proteins with the products of tumor suppressor genes.

Authors:  K Vousden
Journal:  FASEB J       Date:  1993-07       Impact factor: 5.191

9.  Collaborative United Kingdom-Australasian study of cancer in patients treated with immunosuppressive drugs.

Authors:  L J Kinlen; A G Sheil; J Peto; R Doll
Journal:  Br Med J       Date:  1979-12-08

10.  Cervical carcinoma: low frequency of allele loss at loci implicated in other common malignancies.

Authors:  R M Busby-Earle; C M Steel; C C Bird
Journal:  Br J Cancer       Date:  1993-01       Impact factor: 7.640
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  4 in total

1.  Single nucleotide polymorphism array analysis defines a specific genetic fingerprint for well-differentiated cutaneous SCCs.

Authors:  Karin J Purdie; Catherine A Harwood; Abha Gulati; Tracy Chaplin; Sally R Lambert; Rino Cerio; Gavin P Kelly; Jean-Baptiste Cazier; Bryan D Young; Irene M Leigh; Charlotte M Proby
Journal:  J Invest Dermatol       Date:  2009-01-08       Impact factor: 8.551

2.  Analysis of p16 expression and allelic imbalance / loss of heterozygosity of 9p21 in cutaneous squamous cell carcinomas.

Authors:  Sarah E Gray; Elaine Kay; Mary Leader; M Mabruk
Journal:  J Cell Mol Med       Date:  2006 Jul-Sep       Impact factor: 5.310

3.  Allelic imbalances and microdeletions affecting the PTPRD gene in cutaneous squamous cell carcinomas detected using single nucleotide polymorphism microarray analysis.

Authors:  Karin J Purdie; Sally R Lambert; Muy-Teck Teh; Tracy Chaplin; Gael Molloy; Manoj Raghavan; David P Kelsell; Irene M Leigh; Catherine A Harwood; Charlotte M Proby; Bryan D Young
Journal:  Genes Chromosomes Cancer       Date:  2007-07       Impact factor: 5.006

4.  Molecular profiling of cutaneous squamous cell carcinomas and actinic keratoses from organ transplant recipients.

Authors:  Liesbeth Hameetman; Suzan Commandeur; Jan Nico Bouwes Bavinck; Hermina C Wisgerhof; Frank R de Gruijl; Rein Willemze; Leon Mullenders; Cornelis P Tensen; Harry Vrieling
Journal:  BMC Cancer       Date:  2013-02-05       Impact factor: 4.430
  4 in total

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