BACKGROUND: Epithelioid sarcoma is a rare histologic subtype of sarcoma. The clinical behavior and prognostic factors influencing survival in this disease are examined. METHODS: A review of clinicopathologic features of patients with epithelioid sarcoma prospectively followed between July 1982 and July 1995 at Memorial Sloan-Kettering Cancer Center was performed. Kaplan-Meier and log-rank analysis were used. RESULTS: Eleven men (69%) and five women (31%) were treated during this period. Mean age at diagnosis was 33 years, and length of symptoms before diagnosis was 18 months. Tumors presented in the trunk in 44% of patients, the lower extremity in 31%, and the upper extremity in 25%. Median follow-up time was 45 months. At least one local recurrence was experienced by 69% of patients. Metastases to regional lymph nodes during the course of the disease developed in 44% of patients and to the lungs in 44%. Median survival was 88.8 months, with a 66% 5-year survival rate. Pulmonary metastasis was correlated with decreased survival. CONCLUSIONS: A delay in diagnosis of epithelioid sarcoma is common. Epithelioid sarcoma differs from other sarcoma subtypes in propensity for nodal spread and local recurrence. Careful follow-up evaluating local recurrence, nodal spread, and pulmonary metastases is warranted.
BACKGROUND:Epithelioid sarcoma is a rare histologic subtype of sarcoma. The clinical behavior and prognostic factors influencing survival in this disease are examined. METHODS: A review of clinicopathologic features of patients with epithelioid sarcoma prospectively followed between July 1982 and July 1995 at Memorial Sloan-Kettering Cancer Center was performed. Kaplan-Meier and log-rank analysis were used. RESULTS: Eleven men (69%) and five women (31%) were treated during this period. Mean age at diagnosis was 33 years, and length of symptoms before diagnosis was 18 months. Tumors presented in the trunk in 44% of patients, the lower extremity in 31%, and the upper extremity in 25%. Median follow-up time was 45 months. At least one local recurrence was experienced by 69% of patients. Metastases to regional lymph nodes during the course of the disease developed in 44% of patients and to the lungs in 44%. Median survival was 88.8 months, with a 66% 5-year survival rate. Pulmonary metastasis was correlated with decreased survival. CONCLUSIONS: A delay in diagnosis of epithelioid sarcoma is common. Epithelioid sarcoma differs from other sarcoma subtypes in propensity for nodal spread and local recurrence. Careful follow-up evaluating local recurrence, nodal spread, and pulmonary metastases is warranted.
Authors: Aniket Sakharpe; Guy Lahat; Taher Gulamhusein; Ping Liu; Svetlana Bolshakov; Theresa Nguyen; Pingyu Zhang; Roman Belousov; Eric Young; Xianbiao Xie; Priya Rao; Jason L Hornick; Alexander J Lazar; Raphael E Pollock; Dina Lev Journal: Oncologist Date: 2011-02-28
Authors: Andreas F Mavrogenis; Georgios N Panagopoulos; Andrea Angelini; Jan Lesenský; Christos Vottis; Panayiotis D Megaloikonomos; Zinon T Kokkalis; Vasilios Kontogeorgakos; Pietro Ruggieri; Panayiotis J Papagelopoulos Journal: Eur J Orthop Surg Traumatol Date: 2017-06-05
Authors: Sebastian Heikaus; Krystian S Matuszek; Christoph V Suschek; Uwe Ramp; Petra Reinecke; Edgar Grinstein; Janine Haremza; Helmut E Gabbert; Csaba Mahotka Journal: J Cancer Res Clin Oncol Date: 2007-12-12 Impact factor: 4.553
Authors: A Daigeler; C Kuhnen; R Moritz; I Stricker; O Goertz; D Tilkorn; L Steinstraesser; H U Steinau; M Lehnhardt Journal: Langenbecks Arch Surg Date: 2008-07-02 Impact factor: 3.445