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Literature DB >> 9309175

Armadillo and dTCF: a marriage made in the nucleus.

Abstract

Within the past year, Armadillo and beta-catenin's role in transducing the Wingless/Wnt signal has been substantially clarified. It is now clear that Armadillo and beta-catenin bind directly to members of the T-cell factor/lymphoid enhancer factor subfamily of HMG box DNA-binding proteins, forming bipartite transcription factors that regulate Wingless/Wnt responsive genes in both Drosophila and vertebrates. These partners not only play key roles in a variety of cell fate decisions during normal development but, when inappropriately activated, contribute to both colon cancer and melanoma.

Entities: Disease Gene Species

Mesh：

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Year: 1997 PMID： 9309175 DOI： 10.1016/s0959-437x(97)80071-8

Source DB: PubMed Journal: Curr Opin Genet Dev ISSN： 0959-437X Impact factor: 5.578

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Cited

14 in total

1. beta-catenin can be transported into the nucleus in a Ran-unassisted manner.

Authors: F Yokoya; N Imamoto; T Tachibana; Y Yoneda
Journal: Mol Biol Cell Date: 1999-04 Impact factor: 4.138

Review 2. Beyond good and evil in the oral cavity: insights into host-microbe relationships derived from transcriptional profiling of gingival cells.

Authors: M Handfield; H V Baker; R J Lamont
Journal: J Dent Res Date: 2008-03 Impact factor: 6.116

3. A novel homeobox gene mediates the Dpp signal to establish functional specificity within target cells.

Authors: H Nakagoshi; M Hoshi; Y Nabeshima; F Matsuzaki
Journal: Genes Dev Date: 1998-09-01 Impact factor: 11.361

4. A high throughput screen to identify secreted and transmembrane proteins involved in Drosophila embryogenesis.

Authors: C C Kopczynski; J N Noordermeer; T L Serano; W Y Chen; J D Pendleton; S Lewis; C S Goodman; G M Rubin
Journal: Proc Natl Acad Sci U S A Date: 1998-08-18 Impact factor: 11.205

5. Seven Wnt homologues in Drosophila: a case study of the developing tracheae.

Authors: M Llimargas; P A Lawrence
Journal: Proc Natl Acad Sci U S A Date: 2001-11-20 Impact factor: 11.205

6. Beta-catenin-histone deacetylase interactions regulate the transition of LEF1 from a transcriptional repressor to an activator.

Authors: A N Billin; H Thirlwell; D E Ayer
Journal: Mol Cell Biol Date: 2000-09 Impact factor: 4.272

Armadillo and dTCF: a marriage made in the nucleus.

1. beta-catenin can be transported into the nucleus in a Ran-unassisted manner.

Review 2. Beyond good and evil in the oral cavity: insights into host-microbe relationships derived from transcriptional profiling of gingival cells.

3. A novel homeobox gene mediates the Dpp signal to establish functional specificity within target cells.

4. A high throughput screen to identify secreted and transmembrane proteins involved in Drosophila embryogenesis.

5. Seven Wnt homologues in Drosophila: a case study of the developing tracheae.

6. Beta-catenin-histone deacetylase interactions regulate the transition of LEF1 from a transcriptional repressor to an activator.

7. The Wnt/Wg signal transducer beta-catenin controls fibronectin expression.

8. The transcriptional repressor Brinker antagonizes Wingless signaling.

9. Direct involvement of N-cadherin-mediated signaling in muscle differentiation.

10. The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway.