Literature DB >> 930808

Results of a two year chronic toxicity study with hexachlorobutadiene in rats.

R J Kociba, D G Keyes, G C Jersey, J J Ballard, D A Dittenber, J F Quast, C E Wade, C G Humiston, B A Schwetz.   

Abstract

Lifetime ingestion by rats of 0.2 mg/kg/day of hexachlorobutadiene caused no discernible ill effects. Slight degrees of primarily renal toxicity occurred with 2 mg/kg/day; 20 mg/kg/day caused multiple toxic effects, including renal tubular neoplasms.

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Year:  1977        PMID: 930808     DOI: 10.1080/00028897708984403

Source DB:  PubMed          Journal:  Am Ind Hyg Assoc J        ISSN: 0002-8894


  6 in total

1.  Mapping Adverse Outcome Pathways for Kidney Injury as a Basis for the Development of Mechanism-Based Animal-Sparing Approaches to Assessment of Nephrotoxicity.

Authors:  Angela Mally; Sebastian Jarzina
Journal:  Front Toxicol       Date:  2022-06-15

2.  The acute toxic effects of hexachloro-1 : 3-butadiene on the rat kidney.

Authors:  E A Lock; J Ishmael
Journal:  Arch Toxicol       Date:  1979-10       Impact factor: 5.153

3.  Deacetylation and further metabolism of the mercapturic acid of hexachloro-1,3-butadiene by rat kidney cytosol in vitro.

Authors:  I S Pratt; E A Lock
Journal:  Arch Toxicol       Date:  1988       Impact factor: 5.153

4.  Land contamination and urinary abnormalities: cause for concern?

Authors:  B Staples; M L P Howse; H Mason; G M Bell
Journal:  Occup Environ Med       Date:  2003-07       Impact factor: 4.402

5.  Increased incidence of renal cell tumors in a cohort of cardboard workers exposed to trichloroethene.

Authors:  D Henschler; S Vamvakas; M Lammert; W Dekant; B Kraus; B Thomas; K Ulm
Journal:  Arch Toxicol       Date:  1995       Impact factor: 5.153

6.  A carcinogenic potency database of the standardized results of animal bioassays.

Authors:  L S Gold; C B Sawyer; R Magaw; G M Backman; M de Veciana; R Levinson; N K Hooper; W R Havender; L Bernstein; R Peto
Journal:  Environ Health Perspect       Date:  1984-12       Impact factor: 9.031

  6 in total

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