OBJECTIVE: To investigate the additive ocular hypotensive effect of latanoprost on the intraocular pressure (IOP) reduction induced by a suboptimal dose of acetazolamide, a carbonic anhydrase inhibitor. DESIGN: A short-term, randomized, placebo-controlled, double-masked study. PARTICIPANTS: Twenty-four patients with glaucoma with elevated IOPs. INTERVENTION: Acetazolamide 250 mg twice daily from day 1 to day 18. Topical 50 micrograms/ml latanoprost or placebo eye drops bilaterally instilled once daily from day 4 to day 18. MEAN OUTCOME MEASURES: IOP, conjunctival hyperemia. RESULTS: The mean IOP of 19.5 mmHg during acetazolamide treatment was further reduced to 16.8 mmHg after topical administration of latanoprost, i.e., a decrease of 2.9 +/- 2.8 mmHg (15%, P < 0.001). Administration of placebo to patients on acetazolamide resulted in an upward drift of 1.3 mmHg (6%, P = 0.03). A modest but statistically significant increase in conjunctival hyperemia was found in the latanoprost-treated group, but did not affect the masking. CONCLUSIONS: This short-term study indicates that the combination of topically applied latanoprost and a suboptimal dose of systemic carbonic anhydrase inhibitor is useful in the management of glaucoma.
RCT Entities:
OBJECTIVE: To investigate the additive ocular hypotensive effect of latanoprost on the intraocular pressure (IOP) reduction induced by a suboptimal dose of acetazolamide, a carbonic anhydrase inhibitor. DESIGN: A short-term, randomized, placebo-controlled, double-masked study. PARTICIPANTS: Twenty-four patients with glaucoma with elevated IOPs. INTERVENTION: Acetazolamide 250 mg twice daily from day 1 to day 18. Topical 50 micrograms/ml latanoprost or placebo eye drops bilaterally instilled once daily from day 4 to day 18. MEAN OUTCOME MEASURES: IOP, conjunctival hyperemia. RESULTS: The mean IOP of 19.5 mmHg during acetazolamide treatment was further reduced to 16.8 mmHg after topical administration of latanoprost, i.e., a decrease of 2.9 +/- 2.8 mmHg (15%, P < 0.001). Administration of placebo to patients on acetazolamide resulted in an upward drift of 1.3 mmHg (6%, P = 0.03). A modest but statistically significant increase in conjunctival hyperemia was found in the latanoprost-treated group, but did not affect the masking. CONCLUSIONS: This short-term study indicates that the combination of topically applied latanoprost and a suboptimal dose of systemic carbonic anhydrase inhibitor is useful in the management of glaucoma.
Authors: Tin Aung; Paul T K Chew; Francis T S Oen; Yiong-Huak Chan; Lennard H Thean; Leonard Yip; Boon-Ang Lim; Jade Soh; Steve K L Seah Journal: Br J Ophthalmol Date: 2002-01 Impact factor: 4.638