Literature DB >> 9307042

Interaction of Ras with phosphoinositide 3-kinase gamma.

I Rubio1, P Rodriguez-Viciana, J Downward, R Wetzker.   

Abstract

Phosphoinositide 3-kinase gamma (PI3Kgamma) can be activated in vitro by both alpha and betagamma subunits of heterotrimeric G-proteins and does not interact with p85, the regulatory subunit of PI3Kalpha. Here we demonstrate the binding of Ras to PI3Kgamma in vitro. An N-terminal region of PI3Kgamma was identified as a binding site for Ras. After co-expression with PI3Kgamma in COS-7 cells, Ras induced only a modest increase in PI3K activity compared with the stimulation of PI3Kalpha by Ras in the same cells.

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Year:  1997        PMID： 9307042      PMCID： PMC1218747          DOI： 10.1042/bj3260891

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  17 in total

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2.  Phosphatidylinositol-3-OH kinase as a direct target of Ras.

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  23 in total

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