OBJECTIVE: To characterise risk factors for abnormal and cytology and anal human papilloma virus (HPV) infection in homosexual/bisexual men with advanced HIV related immunosuppression. DESIGN: Cross sectional study of men with Centers for Disease Control group IV HIV disease. SETTING: The University of California San Francisco, AIDS Clinic. PATIENTS: 129 homosexual or bisexual men with group IV HIV disease. METHODS: A questionnaire was administered detailing tobacco, alcohol and recreational drug use, medical history, and sexual practices. Anal swabs for cytology and HPV studies were obtained, as was blood for CD4 levels. MAIN OUTCOME MEASURES: Abnormal anal cytology and anal HPV infection. RESULTS: Abnormal anal cytology was detected in 39% of subjects and anal HPV infection in 93% as measured by polymerase chain reaction (PCR). Risk factors for abnormal cytology in multivariate analysis included HPV 16/18 infection (measured by PCR, RR = 2.1, 95% CI = 1.2-3.5) and intravenous drug use (RR = 1.8, 95% CI = 1.2-2.7). Infection with HPV 6/11 also had significantly elevated RRs in a separate model. Cigarette smoking, alcohol use, recreational drug use, and low CD4 level were associated with abnormal anal cytology in univariate analysis, as was infection with multiple HPV types and high levels of hybrid capture group B viral DNA. CONCLUSIONS: Anal cytological abnormalities and HPV infection are common among homosexual/bisexual men with group IV HIV disease. In this study population, the main risk factors for abnormal cytology were HPV infection and intravenous drug use.
OBJECTIVE: To characterise risk factors for abnormal and cytology and anal human papilloma virus (HPV) infection in homosexual/bisexual men with advanced HIV related immunosuppression. DESIGN: Cross sectional study of men with Centers for Disease Control group IV HIV disease. SETTING: The University of California San Francisco, AIDS Clinic. PATIENTS: 129 homosexual or bisexual men with group IV HIV disease. METHODS: A questionnaire was administered detailing tobacco, alcohol and recreational drug use, medical history, and sexual practices. Anal swabs for cytology and HPV studies were obtained, as was blood for CD4 levels. MAIN OUTCOME MEASURES: Abnormal anal cytology and anal HPV infection. RESULTS: Abnormal anal cytology was detected in 39% of subjects and anal HPV infection in 93% as measured by polymerase chain reaction (PCR). Risk factors for abnormal cytology in multivariate analysis included HPV 16/18 infection (measured by PCR, RR = 2.1, 95% CI = 1.2-3.5) and intravenous drug use (RR = 1.8, 95% CI = 1.2-2.7). Infection with HPV 6/11 also had significantly elevated RRs in a separate model. Cigarette smoking, alcohol use, recreational drug use, and low CD4 level were associated with abnormal anal cytology in univariate analysis, as was infection with multiple HPV types and high levels of hybrid capture group B viral DNA. CONCLUSIONS: Anal cytological abnormalities and HPV infection are common among homosexual/bisexual men with group IV HIV disease. In this study population, the main risk factors for abnormal cytology were HPV infection and intravenous drug use.
Authors: J R Daling; N S Weiss; T G Hislop; C Maden; R J Coates; K J Sherman; R L Ashley; M Beagrie; J A Ryan; L Corey Journal: N Engl J Med Date: 1987-10-15 Impact factor: 91.245
Authors: D Caussy; J J Goedert; J Palefsky; J Gonzales; C S Rabkin; R A DiGioia; W C Sanchez; R J Grossman; G Colclough; S Z Wiktor Journal: Int J Cancer Date: 1990-08-15 Impact factor: 7.396
Authors: M Melbye; J Palefsky; J Gonzales; L P Ryder; H Nielsen; O Bergmann; J Pindborg; R J Biggar Journal: Int J Cancer Date: 1990-08-15 Impact factor: 7.396
Authors: F X Bosch; N Muñoz; S de Sanjosé; I Izarzugaza; M Gili; P Viladiu; M J Tormo; P Moreo; N Ascunce; L C Gonzalez Journal: Int J Cancer Date: 1992-11-11 Impact factor: 7.396
Authors: N B Kiviat; C W Critchlow; K K Holmes; J Kuypers; J Sayer; C Dunphy; C Surawicz; P Kirby; R Wood; J R Daling Journal: AIDS Date: 1993-01 Impact factor: 4.177
Authors: M H Schiffman; H M Bauer; R N Hoover; A G Glass; D M Cadell; B B Rush; D R Scott; M E Sherman; R J Kurman; S Wacholder Journal: J Natl Cancer Inst Date: 1993-06-16 Impact factor: 13.506
Authors: C W Critchlow; C M Surawicz; K K Holmes; J Kuypers; J R Daling; S E Hawes; G M Goldbaum; J Sayer; C Hurt; C Dunphy Journal: AIDS Date: 1995-11 Impact factor: 4.177
Authors: Sandra Barbeiro; Catarina Atalaia-Martins; Pedro Marcos; Cláudia Gonçalves; Isabel Cotrim; Helena Vasconcelos Journal: GE Port J Gastroenterol Date: 2016-11-30
Authors: Malin T Engelmark; Emma L Ivansson; Jessica J Magnusson; Inger M Gustavsson; Per-Ivan Wyöni; Max Ingman; Patrik K E Magnusson; Ulf B Gyllensten Journal: Hum Genet Date: 2008-04-08 Impact factor: 4.132