Literature DB >> 9304669

Genetic diversity and disease susceptibility.

W F Bodmer1.   

Abstract

The range of genetic diversity within human populations is enormous. Genetic susceptibility to common chronic disease is a significant part of this genetic diversity, which also includes a variety of rare clear-cut inherited diseases. Modern DNA-based genomic analysis can now routinely lead to the identification of genes involved in disease susceptibility, provides the basis for genetic counselling in affected families, and more widely for a genetically targeted approach to disease prevention. This naturally raises problems concerning the use of information on an individual's decisions, but for employment, and health and life insurance.

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Year:  1997        PMID: 9304669      PMCID: PMC1691996          DOI: 10.1098/rstb.1997.0083

Source DB:  PubMed          Journal:  Philos Trans R Soc Lond B Biol Sci        ISSN: 0962-8436            Impact factor:   6.237


  5 in total

Review 1.  The HLA system and the analysis of multifactorial genetic disease.

Authors:  I P Tomlinson; W F Bodmer
Journal:  Trends Genet       Date:  1995-12       Impact factor: 11.639

Review 2.  Molecular genetic basis of colorectal cancer susceptibility.

Authors:  C Cunningham; M G Dunlop
Journal:  Br J Surg       Date:  1996-03       Impact factor: 6.939

3.  Clinical diagnosis of ankylosing spondylitis in women and relation to presence of HLA-B27.

Authors:  H F Hill; A G Hill; J G Bodmer
Journal:  Ann Rheum Dis       Date:  1976-06       Impact factor: 19.103

Review 4.  Inherited breast and ovarian cancer.

Authors:  C I Szabo; M C King
Journal:  Hum Mol Genet       Date:  1995       Impact factor: 6.150

Review 5.  Cancer genetics.

Authors:  W F Bodmer
Journal:  Br Med Bull       Date:  1994-07       Impact factor: 4.291

  5 in total

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