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Literature DB >> 9303379

Cerebrospinal fluid bactericidal activity against cephalosporin-resistant Streptococcus pneumoniae in children with meningitis treated with high-dosage cefotaxime.

Abstract

We determined cefotaxime and desacetyl-cefotaxime concentrations in children with bacterial meningitis receiving high-dose cefotaxime (300 mg/kg of body weight/day) and concomitant dexamethasone therapy. The median peak cerebrospinal fluid cefotaxime and desacetyl-cefotaxime concentrations were 4.7 and 8.1 microg/ml, respectively. In vitro bactericidal activity (>99.9% killing in 6 h) was found in 17 (94%), 13 (72%), and 8 (44%) of 18 cerebrospinal fluid specimens against cefotaxime-susceptible, -intermediate (MIC, 1 microg/ml), and -resistant (MIC, 4 microg/ml) strains, respectively. High-dose cefotaxime, while safe, is not reliably sufficient therapy for cephalosporin-nonsusceptible pneumococcal meningitis, and combination therapy is recommended.

Entities: Chemical Disease Gene Species

Mesh：

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Year: 1997 PMID： 9303379 PMCID： PMC164030 DOI： 10.1128/AAC.41.9.1888

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

20 in total

1. Antimicrobial resistance of Streptococcus pneumoniae recovered from outpatients in the United States during the winter months of 1994 to 1995: results of a 30-center national surveillance study.

Authors: G V Doern; A Brueggemann; H P Holley; A M Rauch
Journal: Antimicrob Agents Chemother Date: 1996-05 Impact factor: 5.191

2. Failure of cefotaxime treatment in a patient with penicillin-resistant pneumococcal meningitis and confirmation of nosocomial spread by random amplified polymorphic DNA analysis.

Authors: J Raymond; E Bingen; C Doit; N Brahimi; M Bergeret; J Badoual; D Gendrel
Journal: Clin Infect Dis Date: 1995-07 Impact factor: 9.079

3. Meningitis due to ceftriaxone-resistant Streptococcus pneumoniae.

Authors: J R Lonks; M R Durkin; A N Meyerhoff; A A Medeiros
Journal: N Engl J Med Date: 1995-03-30 Impact factor: 91.245

4. Determination of cefsulodin, cefotiam, cephalexin, cefotaxime, desacetyl-cefotaxime, cefuroxime and cefroxadin in plasma and urine by high-performance liquid chromatography.

Authors: J B Lecaillon; M C Rouan; C Souppart; N Febvre; F Juge
Journal: J Chromatogr Date: 1982-03-12

5. High doses of cefotaxime in treatment of adult meningitis due to Streptococcus pneumoniae with decreased susceptibilities to broad-spectrum cephalosporins.

Authors: P F Viladrich; C Cabellos; R Pallares; F Tubau; J Martínez-Lacasa; J Liñares; F Gudiol
Journal: Antimicrob Agents Chemother Date: 1996-01 Impact factor: 5.191

6. Relationship of MICs to efficacy of cefotaxime in treatment of Streptococcus pneumoniae infections.

Authors: R F Jacobs; S L Kaplan; G E Schutze; A S Dajani; R J Leggiadro; C S Rim; S K Puri
Journal: Antimicrob Agents Chemother Date: 1996-04 Impact factor: 5.191

7. Influence of dexamethasone on efficacy of ceftriaxone and vancomycin therapy in experimental pneumococcal meningitis.

Authors: C Cabellos; J Martinez-Lacasa; A Martos; F Tubau; A Fernández; P F Viladrich; F Gudiol
Journal: Antimicrob Agents Chemother Date: 1995-09 Impact factor: 5.191

8. Bactericidal activity against cephalosporin-resistant Streptococcus pneumoniae in cerebrospinal fluid of children with acute bacterial meningitis.

Authors: K P Klugman; I R Friedland; J S Bradley
Journal: Antimicrob Agents Chemother Date: 1995-09 Impact factor: 5.191

9. Time-kill studies of antibiotic combinations against penicillin-resistant and -susceptible Streptococcus pneumoniae.

Authors: I R Friedland; M Paris; S Shelton; G H McCracken
Journal: J Antimicrob Chemother Date: 1994-08 Impact factor: 5.790

10. Cefotaxime diffusion into cerebrospinal fluid of children with meningitis.

Authors: B I Asmar; M C Thirumoorthi; J A Buckley; D M Kobos; A S Dajani
Journal: Antimicrob Agents Chemother Date: 1985-07 Impact factor: 5.191

11 in total

Review 1. Determination of fungicidal activities against yeasts and molds: lessons learned from bactericidal testing and the need for standardization.

Authors: M A Pfaller; D J Sheehan; J H Rex
Journal: Clin Microbiol Rev Date: 2004-04 Impact factor: 26.132

10. Dexamethasone and antibiotics for the empirical treatment of bacterial meningitis in Canadian children: A survey of paediatric infectious diseases specialists.

Authors: Bjk Tan; Hd Davies
Journal: Paediatr Child Health Date: 2002-07 Impact factor: 2.253

Cerebrospinal fluid bactericidal activity against cephalosporin-resistant Streptococcus pneumoniae in children with meningitis treated with high-dosage cefotaxime.

1. Antimicrobial resistance of Streptococcus pneumoniae recovered from outpatients in the United States during the winter months of 1994 to 1995: results of a 30-center national surveillance study.

2. Failure of cefotaxime treatment in a patient with penicillin-resistant pneumococcal meningitis and confirmation of nosocomial spread by random amplified polymorphic DNA analysis.

3. Meningitis due to ceftriaxone-resistant Streptococcus pneumoniae.

4. Determination of cefsulodin, cefotiam, cephalexin, cefotaxime, desacetyl-cefotaxime, cefuroxime and cefroxadin in plasma and urine by high-performance liquid chromatography.

5. High doses of cefotaxime in treatment of adult meningitis due to Streptococcus pneumoniae with decreased susceptibilities to broad-spectrum cephalosporins.

6. Relationship of MICs to efficacy of cefotaxime in treatment of Streptococcus pneumoniae infections.

7. Influence of dexamethasone on efficacy of ceftriaxone and vancomycin therapy in experimental pneumococcal meningitis.

8. Bactericidal activity against cephalosporin-resistant Streptococcus pneumoniae in cerebrospinal fluid of children with acute bacterial meningitis.

9. Time-kill studies of antibiotic combinations against penicillin-resistant and -susceptible Streptococcus pneumoniae.

10. Cefotaxime diffusion into cerebrospinal fluid of children with meningitis.

Review 1. Determination of fungicidal activities against yeasts and molds: lessons learned from bactericidal testing and the need for standardization.

2. Therapy of suspected bacterial meningitis in Canadian children six weeks of age and older.

Review 3. Pharmacokinetics and pharmacodynamics of cephalosporins in cerebrospinal fluid.

Review 4. Penicillin- and cephalosporin-resistant Streptococcus pneumoniae. Emerging treatment for an emerging problem.

5. Pharmacodynamic evaluation of meropenem and cefotaxime for pediatric meningitis: a report from the OPTAMA program.

6. Treatment of Bacterial Meningitis.

Review 7. Pharmacokinetics of antibacterial agents in the CSF of children and adolescents.

Review 8. Pharmacokinetic optimisation of the treatment of bacterial central nervous system infections.

Review 9. Management of infections due to antibiotic-resistant Streptococcus pneumoniae.

10. Dexamethasone and antibiotics for the empirical treatment of bacterial meningitis in Canadian children: A survey of paediatric infectious diseases specialists.