Literature DB >> 9302296

Repair of adult rat corticospinal tract by transplants of olfactory ensheathing cells.

Y Li1, P M Field, G Raisman.   

Abstract

The upper cervical corticospinal tract was transected on one side in adult rats. A suspension of ensheathing cells cultured from adult rat olfactory bulb was injected into the lesion site. This induced unbranched, elongative growth of the cut corticospinal axons. The axons grew through the transplant and continued to regenerate into the denervated caudal host tract. Rats with complete transections and no transplanted cells did not use the forepaw on the lesioned side for directed reaching. Rats in which the transplanted cells had formed a continuous bridge across the lesion exhibited directed forepaw reaching on the lesioned side.

Entities:  

Mesh：

Year:  1997        PMID： 9302296     DOI： 10.1126/science.277.5334.2000

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  156 in total

1.  Activation of locomotion in adult chronic spinal rats is achieved by transplantation of embryonic raphe cells reinnervating a precise lumbar level.

Authors:  M G Ribotta; J Provencher; D Feraboli-Lohnherr; S Rossignol; A Privat; D Orsal
Journal:  J Neurosci       Date:  2000-07-01       Impact factor: 6.167

2.  Selective innervation of retinorecipient brainstem nuclei by retinal ganglion cell axons regenerating through peripheral nerve grafts in adult rats.

Authors:  M Avilés-Trigueros; Y Sauvé; R D Lund; M Vidal-Sanz
Journal:  J Neurosci       Date:  2000-01-01       Impact factor: 6.167

3.  Adult neuronal regeneration induced by transgenic integrin expression.

Authors:  M L Condic
Journal:  J Neurosci       Date:  2001-07-01       Impact factor: 6.167

4.  Locomotor recovery in spinal cord-injured rats treated with an antibody neutralizing the myelin-associated neurite growth inhibitor Nogo-A.

Authors:  D Merkler; G A Metz; O Raineteau; V Dietz; M E Schwab; K Fouad
Journal:  J Neurosci       Date:  2001-05-15       Impact factor: 6.167

Review 5.  The transitional zone and CNS regeneration.

Authors:  J P Fraher
Journal:  J Anat       Date:  1999-02       Impact factor: 2.610

6.  LacZ-expressing olfactory ensheathing cells do not associate with myelinated axons after implantation into the compressed spinal cord.

Authors:  J G Boyd; J Lee; V Skihar; R Doucette; M D Kawaja
Journal:  Proc Natl Acad Sci U S A       Date:  2004-02-05       Impact factor: 11.205

7.  Transplantation of olfactory ensheathing cells into spinal cord lesions restores breathing and climbing.

Authors:  Ying Li; Patrick Decherchi; Geoffrey Raisman
Journal:  J Neurosci       Date:  2003-02-01       Impact factor: 6.167

8.  Transplantation of olfactory mucosa minimizes axonal branching and promotes the recovery of vibrissae motor performance after facial nerve repair in rats.

Authors:  Orlando Guntinas-Lichius; Konstantin Wewetzer; Toma L Tomov; Natalie Azzolin; Shohreh Kazemi; Michael Streppel; Wolfrum F Neiss; Doychin N Angelov
Journal:  J Neurosci       Date:  2002-08-15       Impact factor: 6.167

Review 9.  Central nervous system lesions that can and those that cannot be repaired with the help of olfactory bulb ensheathing cell transplants.

Authors:  Manuel Nieto-Sampedro
Journal:  Neurochem Res       Date:  2003-11       Impact factor: 3.996

10.  Axonal degeneration as a self-destructive defense mechanism against neurotropic virus infection.

Authors:  Ikuo Tsunoda
Journal:  Future Virol       Date:  2008       Impact factor: 1.831
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