| Literature DB >> 9302276 |
G A Carlson1, D R Borchelt, A Dake, S Turner, V Danielson, J D Coffin, C Eckman, J Meiners, S P Nilsen, S G Younkin, K K Hsiao.
Abstract
Overexpression of Alzheimer amyloid precursor protein (APP) produces dramatically different phenotypes in transgenic mice depending on the genetic background. For example, concentrations of APP that produce amyloid plaques in outbred transgenic lines are lethal for inbred FVB/N or C57BL/6J mice. Expression of SOD1 transgenes is protective, suggesting involvement of oxidative damage in premature death, but ablation of Apoe had no significant effect. In contrast, FGF2 transgene overexpression enhances the lethal effects of APP. Differential survival does not appear to reflect genetic differences in APP processing, but rather host responses to APP or its derivatives.Entities:
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Year: 1997 PMID： 9302276 DOI： 10.1093/hmg/6.11.1951
Source DB: PubMed Journal: Hum Mol Genet ISSN： 0964-6906 Impact factor: 6.150