Literature DB >> 9302220

Antibodies to the hepatitis B e antigen (HBeAg) can be induced in HBeAg-transgenic mice by adoptive transfer of a specific T-helper 2 cell clone.

C Hultgren1, D R Milich, M Sällberg.   

Abstract

Production of antibody to hepatitis B e antigen (HBeAg); i.e., anti-HBe antibody,) in HBeAg-transgenic mice is believed to be mediated by T-helper 2 (Th2) cells. Injection of an HBeAg-specific Th2 clone into HBeAg-transgenic H-2k mice induced anti-HBe antibody production, confirming the function of Th2 cells in this model system.

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Year:  1997        PMID： 9302220      PMCID： PMC170615          DOI： 10.1128/cdli.4.5.630-632.1997

Source DB:  PubMed          Journal:  Clin Diagn Lab Immunol        ISSN： 1071-412X


  15 in total

1.  Immunogenicity and antigenicity of the ATPase/helicase domain of the hepatitis C virus non-structural 3 protein.

Authors:  M Sällberg; Z X Zhang; M Chen; L Jin; A Birkett; D L Peterson; D R Milich
Journal:  J Gen Virol       Date:  1996-11       Impact factor: 3.891

2.  Is a function of the secreted hepatitis B e antigen to induce immunologic tolerance in utero?

Authors:  D R Milich; J E Jones; J L Hughes; J Price; A K Raney; A McLachlan
Journal:  Proc Natl Acad Sci U S A       Date:  1990-09       Impact factor: 11.205

Review 3.  The Th1/Th2 balance in autoimmunity.

Authors:  B Charlton; K J Lafferty
Journal:  Curr Opin Immunol       Date:  1995-12       Impact factor: 7.486

4.  Different cytokine profiles of intraphepatic T cells in chronic hepatitis B and hepatitis C virus infections.

Authors:  A Bertoletti; M M D'Elios; C Boni; M De Carli; A L Zignego; M Durazzo; G Missale; A Penna; F Fiaccadori; G Del Prete; C Ferrari
Journal:  Gastroenterology       Date:  1997-01       Impact factor: 22.682

Review 5.  Role of T-cell tolerance in the persistence of hepatitis B virus infection.

Authors:  D R Milich; J Jones; J Hughes; T Maruyama
Journal:  J Immunother Emphasis Tumor Immunol       Date:  1993-10

6.  Characterization of self-reactive T cells that evade tolerance in hepatitis B e antigen transgenic mice.

Authors:  D R Milich; F Schödel; D L Peterson; J E Jones; J L Hughes
Journal:  Eur J Immunol       Date:  1995-06       Impact factor: 5.532

7.  Serology of acute exacerbation in chronic hepatitis B virus infection.

Authors:  T Maruyama; S Iino; K Koike; K Yasuda; D R Milich
Journal:  Gastroenterology       Date:  1993-10       Impact factor: 22.682

8.  Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

Authors:  T R Mosmann; H Cherwinski; M W Bond; M A Giedlin; R L Coffman
Journal:  J Immunol       Date:  1986-04-01       Impact factor: 5.422

9.  Preferential recognition of hepatitis B nucleocapsid antigens by Th1 or Th2 cells is epitope and major histocompatibility complex dependent.

Authors:  D R Milich; D L Peterson; F Schödel; J E Jones; J L Hughes
Journal:  J Virol       Date:  1995-05       Impact factor: 5.103

10.  Activation of a heterogeneous hepatitis B (HB) core and e antigen-specific CD4+ T-cell population during seroconversion to anti-HBe and anti-HBs in hepatitis B virus infection.

Authors:  M C Jung; H M Diepolder; U Spengler; E A Wierenga; R Zachoval; R M Hoffmann; D Eichenlaub; G Frösner; H Will; G R Pape
Journal:  J Virol       Date:  1995-06       Impact factor: 5.103
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