BACKGROUND: Helicobacter pylori is a human pathogen that colonises the gastric mucosa and causes permanent gastric inflammation. AIMS: To assess the symptoms of H pylori infection in an adult unselected population. SUBJECTS: A random sample of 3589 adult Danes who were examined in 1982 and 1987 (n = 2987). METHODS: Abdominal symptoms within the preceding year were recorded at both attendances. Circulating IgG antibodies against H pylori in serum samples drawn in 1982 were measured by using in-house indirect enzyme linked immunosorbent assays (ELISA). RESULTS: People with increased levels of IgG antibodies to H pylori were more likely than uninfected individuals to report heartburn (odds ratio (OR) = 1.26, 95% confidence interval (CI) 1.03-1.54) and abdominal pain characterised by daily length (OR = 1.33, 95% CI 0.92-1.91), nocturnal occurrence (OR = 1.62, 95% CI 1.19-2.19), spring aggravation (OR = 1.68, 95% CI 0.70-4.05), and no relation to meals (OR = 0.62, 95% CI 0.43-0.91) or stress (OR = 0.69, 95% CI 0.50-0.95). The inclusion of people with increased levels of IgG antibodies to H pylori, but without upper dyspepsia, at study entry significantly increased the likelihood of reporting upper dyspepsia at follow up (OR = 1.71, 95% CI 1.24-2.36). People with epigastric pain and increased levels of IgM antibodies to H pylori only indicative of acute H pylori infection were more likely to report nocturnal pain, heartburn, nausea, and vomiting. CONCLUSION: H pylori infection may precede the development of dyspepsia and is associated with a variety of gastrointestinal symptoms in people with no history of peptic ulcer disease.
BACKGROUND:Helicobacter pylori is a human pathogen that colonises the gastric mucosa and causes permanent gastric inflammation. AIMS: To assess the symptoms of H pylori infection in an adult unselected population. SUBJECTS: A random sample of 3589 adult Danes who were examined in 1982 and 1987 (n = 2987). METHODS: Abdominal symptoms within the preceding year were recorded at both attendances. Circulating IgG antibodies against H pylori in serum samples drawn in 1982 were measured by using in-house indirect enzyme linked immunosorbent assays (ELISA). RESULTS:People with increased levels of IgG antibodies to H pylori were more likely than uninfected individuals to report heartburn (odds ratio (OR) = 1.26, 95% confidence interval (CI) 1.03-1.54) and abdominal pain characterised by daily length (OR = 1.33, 95% CI 0.92-1.91), nocturnal occurrence (OR = 1.62, 95% CI 1.19-2.19), spring aggravation (OR = 1.68, 95% CI 0.70-4.05), and no relation to meals (OR = 0.62, 95% CI 0.43-0.91) or stress (OR = 0.69, 95% CI 0.50-0.95). The inclusion of people with increased levels of IgG antibodies to H pylori, but without upper dyspepsia, at study entry significantly increased the likelihood of reporting upper dyspepsia at follow up (OR = 1.71, 95% CI 1.24-2.36). People with epigastric pain and increased levels of IgM antibodies to H pylori only indicative of acute H pylori infection were more likely to report nocturnal pain, heartburn, nausea, and vomiting. CONCLUSION:H pylori infection may precede the development of dyspepsia and is associated with a variety of gastrointestinal symptoms in people with no history of peptic ulcer disease.
Authors: T Rokkas; C Pursey; E Uzoechina; L Dorrington; N A Simmons; M I Filipe; G E Sladen Journal: Am J Gastroenterol Date: 1987-11 Impact factor: 10.864
Authors: A M Caballero-Plasencia; M C Muros-Navarro; J L Martín-Ruiz; M Valenzuela-Barranco; M C de los Reyes-García; F J Casado-Caballero; M Rodríguez-Téllez; J G López-Mañas Journal: Scand J Gastroenterol Date: 1995-08 Impact factor: 2.423
Authors: D Vaira; N Vakil; M Rugge; L Gatta; C Ricci; M Menegatti; G Leandro; J Holton; V M Russo; M Miglioli Journal: Gut Date: 2003-11 Impact factor: 23.059