GM and KM allotypes in nine population samples of Sicily.

Serum samples of 864 unrelated healthy male and female individuals belonging to nine provinces of Sicily were types for Glm (1,2,3,17), G3m (5,10,11,13,14,15,16,21), and KM (1). With the exception of the Trapani sample these samples are characterized by the presence of five GM haplotypes: GM*1,17;21,26; GM*1,2,17;21,26; GM*1,3;5,10,11,13,14,26; GM*3;5,10,13,14,26; and GM*1,17;10,11,13,15,16. The interpopulation variability in the distribution of these haplotypes is considerable, which is especially due to haplotypes GM*1,3;5,10,11,13,14,26, and GM*3;5,10,13,14,26. However, no clear-cut clustering of the samples according to historical or geographical facts could be shown. Comparisons with other Italian populations reveal the considerable genetic difference of the Sicilians, which is in particular caused by the presence of the haplotypes GM*1,3;5,10,11,13,14,26, and GM*1,17;10,11,13,15,16. These haplotypes are quite uncommon in Europeans and may reflect gene flow from the Middle East. The KM phenotype and allele frequencies also show a considerable interpopulation variability among the nine Sicilian samples, but as for GM no distinction between eastern and western provinces of Sicily is present.