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Literature DB >> 9300037

Gene transfer using replication-defective human foamy virus vectors.

P D Bieniasz¹, O Erlwein, A Aguzzi, A Rethwilm, M O McClure.

Abstract

Replication-defective vectors based on an infectious molecular clone of human foamy virus (HFV) were constructed by deletion and replacement of the accessory genes with expression cassettes for puromycin-resistance and beta-glucouronidase. Cell lines which produced in excess of 10(5) helper virus-free transducing units/ml were generated by trans-complementation of the replication defect using a BHK-21-derived cell line expressing the Bel-1 transactivator. Vectors based on the HFV genome may provide useful alternatives to existing retroviral vectors.

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Year: 1997 PMID： 9300037 DOI： 10.1006/viro.1997.8658

Source DB: PubMed Journal: Virology ISSN： 0042-6822 Impact factor: 3.616

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Cited

16 in total

1. Complex effects of deletions in the 5' untranslated region of primate foamy virus on viral gene expression and RNA packaging.

Authors: M Heinkelein; J Thurow; M Dressler; H Imrich; D Neumann-Haefelin; M O McClure; A Rethwilm
Journal: J Virol Date: 2000-04 Impact factor: 5.103

2. Cell cycle requirements for transduction by foamy virus vectors compared to those of oncovirus and lentivirus vectors.

Authors: Grant Trobridge; David W Russell
Journal: J Virol Date: 2004-03 Impact factor: 5.103

Gene transfer using replication-defective human foamy virus vectors.

1. Complex effects of deletions in the 5' untranslated region of primate foamy virus on viral gene expression and RNA packaging.

2. Cell cycle requirements for transduction by foamy virus vectors compared to those of oncovirus and lentivirus vectors.

3. Foamy virus vector integration sites in normal human cells.

Review 4. Grafting mouse brains: from neurocarcinogenesis to neurodegeneration.

5. Characterization of a human foamy virus 170-kilodalton Env-Bet fusion protein generated by alternative splicing.

6. The fourth central polypurine tract guides the synthesis of prototype foamy virus plus-strand DNA.

7. Palindromic sequence plays a critical role in human foamy virus dimerization.

8. Foamy virus nuclear RNA export is distinct from that of other retroviruses.

9. Helper-free foamy virus vectors.

10. Characterization of a cis-acting sequence in the Pol region required to transfer human foamy virus vectors.