Literature DB >> 9299561

Colon adenoma and cancer cells aberrantly express the leukocyte-associated sialoglycoprotein CD43.

R Sikut1, O Nilsson, D Baeckström, G C Hansson.   

Abstract

CD43 (leukosialin) has hitherto been considered as an exclusive leukocyte marker, but now we report the expression of CD43 in the epithelial cells of all studied colorectal adenomas (21/21) and in about 50% (18/34) of adenocarcinomas as analyzed both at the mRNA and protein levels. Direct evidence showing the causal role of CD43 in colon tumorigenesis is lacking, but its involvement in leukocyte activation and impairment of apoptotic response suggests a role for CD43 in colon cancer development. Copyright 1997 Academic Press.

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Year:  1997        PMID： 9299561     DOI： 10.1006/bbrc.1997.7334

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  9 in total

1.  Tumor cell MUC1 and CD43 are glycosylated differently with sialyl-Lewis a and x epitopes and show variable interactions with E-selectin under physiological flow conditions.

Authors:  J Fernandez-Rodriguez; O Dwir; R Alon; G C Hansson
Journal:  Glycoconj J       Date:  2001 Nov-Dec       Impact factor: 2.916

2.  Signaling through CD43 regulates CD4 T-cell trafficking.

Authors:  Purvi D Mody; Judy L Cannon; Hozefa S Bandukwala; Kelly M Blaine; Alexander B Schilling; Kevin Swier; Anne I Sperling
Journal:  Blood       Date:  2007-07-16       Impact factor: 22.113

3.  The cleavage of neutrophil leukosialin (CD43) by cathepsin G releases its extracellular domain and triggers its intramembrane proteolysis by presenilin/gamma-secretase.

Authors:  Agnès Mambole; Dominique Baruch; Patrick Nusbaum; Sylvain Bigot; Misa Suzuki; Philippe Lesavre; Minoru Fukuda; Lise Halbwachs-Mecarelli
Journal:  J Biol Chem       Date:  2008-06-27       Impact factor: 5.157

4.  Mass spectrometry-based identification of the tumor antigen UN1 as the transmembrane CD43 sialoglycoprotein.

Authors:  Annamaria de Laurentiis; Marco Gaspari; Camillo Palmieri; Cristina Falcone; Enrico Iaccino; Giuseppe Fiume; Ornella Massa; Mariorosario Masullo; Franca Maria Tuccillo; Laura Roveda; Ubaldo Prati; Olga Fierro; Immacolata Cozzolino; Giancarlo Troncone; Pierfrancesco Tassone; Giuseppe Scala; Ileana Quinto
Journal:  Mol Cell Proteomics       Date:  2011-03-03       Impact factor: 5.911

5.  Shedding and gamma-secretase-mediated intramembrane proteolysis of the mucin-type molecule CD43.

Authors:  Christian X Andersson; Julia Fernandez-Rodriguez; Sirle Laos; Dan Baeckström; Christian Haass; Gunnar C Hansson
Journal:  Biochem J       Date:  2005-04-15       Impact factor: 3.857

6.  High level expression of CD43 inhibits T cell receptor/CD3-mediated apoptosis.

Authors:  Y W He; M J Bevan
Journal:  J Exp Med       Date:  1999-12-20       Impact factor: 14.307

Review 7.  Aberrant glycosylation as biomarker for cancer: focus on CD43.

Authors:  Franca Maria Tuccillo; Annamaria de Laurentiis; Camillo Palmieri; Giuseppe Fiume; Patrizia Bonelli; Antonella Borrelli; Pierfrancesco Tassone; Iris Scala; Franco Maria Buonaguro; Ileana Quinto; Giuseppe Scala
Journal:  Biomed Res Int       Date:  2014-02-13       Impact factor: 3.411

8.  Intracellular patterns of sialophorin expression define a new molecular classification of breast cancer and represent new targets for therapy.

Authors:  Q Fu; S E Cash; J J Andersen; C R Kennedy; A R Madadi; M Raghavendra; L L Dietrich; W A Agger; C S Shelley
Journal:  Br J Cancer       Date:  2013-11-26       Impact factor: 7.640

Review 9.  Sweet and sour: the impact of differential glycosylation in cancer cells undergoing epithelial-mesenchymal transition.

Authors:  Leonardo Freire-de-Lima
Journal:  Front Oncol       Date:  2014-03-25       Impact factor: 6.244
  9 in total

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