Literature DB >> 9299534

Prolactin stimulates mitogen-activated protein kinase in human leiomyoma cells.

A Nohara1, M Ohmichi, K Koike, H Jikihara, A Kimura, K Masuhara, H Ikegami, M Inoue, A Miyake, Y Murata.   

Abstract

The effects of prolactin (PRL) on proliferation of cultured human uterine leiomyoma-derived smooth muscle cells (SMC) and its mechanism of action were investigated. PRL stimulated DNA synthesis and the expression of PRL receptor was identified by ribonuclease protection assay. Moreover, the regulation of mitogen-activated protein (MAP) kinase by PRL in leiomyoma-derived SMC was investigated. PRL stimulated MAP kinase activity, as detected by 32P incorporation into MAP-2, in a dose-dependent manner. PRL also rapidly stimulated MAP kinase phosphorylation as detected by in vivo phosphorylation using 32P labeling and phosphotyrosine immunoblotting. These results suggest that PRL stimulates the proliferation of human leiomyoma cells via the MAP kinase cascade. Copyright 1997 Academic Press.

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Year:  1997        PMID： 9299534     DOI： 10.1006/bbrc.1997.7322

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  6 in total

1.  Expression profiling of uterine leiomyomata cytogenetic subgroups reveals distinct signatures in matched myometrium: transcriptional profilingof the t(12;14) and evidence in support of predisposing genetic heterogeneity.

Authors:  Jennelle C Hodge; Tae-Min Kim; Jonathan M Dreyfuss; Priya Somasundaram; Nicole C Christacos; Marissa Rousselle; Bradley J Quade; Peter J Park; Elizabeth A Stewart; Cynthia C Morton
Journal:  Hum Mol Genet       Date:  2012-02-17       Impact factor: 6.150

2.  Prolactin is Expressed in Uterine Leiomyomas and Promotes Signaling and Fibrosis in Myometrial Cells.

Authors:  Alessandra DiMauro; Christina Seger; Briaunna Minor; Andrea M Amitrano; Ifunanya Okeke; Manisha Taya; Ashley R Rackow; Divya Kumar; R Matthew Kottman; Bala Bhagavath; Stephen R Hammes
Journal:  Reprod Sci       Date:  2021-11-01       Impact factor: 2.924

3.  Prolactin and prolactin receptor expression in cervical intraepithelial neoplasia and cancer.

Authors:  Rafael Ascencio-Cedillo; Edgar Ivan López-Pulido; José Francisco Muñoz-Valle; Nicolás Villegas-Sepúlveda; Susana Del Toro-Arreola; Ciro Estrada-Chávez; Adrian Daneri-Navarro; Ramón Franco-Topete; Delia Pérez-Montiel; Alejandro García-Carrancá; Ana Laura Pereira-Suárez
Journal:  Pathol Oncol Res       Date:  2014-07-03       Impact factor: 3.201

4.  Increased expression of the prolactin receptor is associated with malignant laryngeal tumors.

Authors:  Luis R González-Lucano; José F Muñoz-Valle; Rafael Ascencio-Cedillo; José A Domínguez-Rosales; Gonzalo López-Rincón; Susana Del Toro-Arreola; Miriam Bueno-Topete; Adrián Daneri-Navarro; Ciro Estrada-Chávez; Ana L Pereira-Suárez
Journal:  Exp Ther Med       Date:  2012-01-30       Impact factor: 2.447

Review 5.  Human Chorionic Gonadotrophin as a Possible Mediator of Leiomyoma Growth during Pregnancy: Molecular Mechanisms.

Authors:  Veronica Sarais; Greta Chiara Cermisoni; Matteo Schimberni; Alessandra Alteri; Enrico Papaleo; Edgardo Somigliana; Paola Vigano'
Journal:  Int J Mol Sci       Date:  2017-09-20       Impact factor: 5.923

6.  The rapid growth of fibroids during early pregnancy.

Authors:  Laura Benaglia; Lucia Cardellicchio; Francesca Filippi; Alessio Paffoni; Paolo Vercellini; Edgardo Somigliana; Luigi Fedele
Journal:  PLoS One       Date:  2014-01-20       Impact factor: 3.240
  6 in total

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