Literature DB >> 9299016

Identification of new medium-chain acylcarnitines present in normal human urine.

R Libert1, F Van Hoof, M Thillaye, M F Vincent, M C Nassogne, V Stroobant, E de Hoffmann, A Schanck.   

Abstract

Analysis of urinary medium-chain acylcarnitines extracted on C18 cartridges and gas chromatography mass spectrometry of their fatty acid moieties as picolinyl esters allowed the determination of the chemical structure of previously unidentified acylcarnitines in normal human urine. These are the 2,6-dimethylheptanoyl-, the 2,6-dimethyl-5-heptenoyl-, and the trans- and cis-3,4-methylene heptanoylcarnitines, also named 3-cyclopropane octanoylcarnitines. Assessment of the structure of these cyclopropane derivatives was obtained by 1H and 13C nuclear magnetic resonance spectroscopy. In addition, other acylcarnitines were tentatively identified. Copyright 1997 Academic Press.

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Year:  1997        PMID： 9299016     DOI： 10.1006/abio.1997.2274

Source DB:  PubMed          Journal:  Anal Biochem        ISSN： 0003-2697            Impact factor:   3.365


  6 in total

1.  Acylcarnitines in fibroblasts of patients with long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency and other fatty acid oxidation disorders.

Authors:  J J Shen; D Matern; D S Millington; S Hillman; M D Feezor; M J Bennett; M Qumsiyeh; S G Kahler; Y T Chen; J L Van Hove
Journal:  J Inherit Metab Dis       Date:  2000-02       Impact factor: 4.982

2.  Picolinyl ester fragmentation mechanism studies with application to the identification of acylcarnitine acyl groups following transesterification.

Authors:  Shuming Yang; Paul Minkler; Charles Hoppel; Kou-Yi Tserng
Journal:  J Am Soc Mass Spectrom       Date:  2006-08-09       Impact factor: 3.109

3.  Identification of new medium-chain acylcarnitines present in urine of a patient with medium-chain acyl-CoA dehydrogenase deficiency.

Authors:  R Libert; F Van Hoof; M Thillaye; M F Vincent; M C Nassogne; V Stroobant; E de Hoffmann; A Schanck
Journal:  J Inherit Metab Dis       Date:  1999-02       Impact factor: 4.982

4.  Fecal Microbiota Transplantation in Experimental Ulcerative Colitis Reveals Associated Gut Microbial and Host Metabolic Reprogramming.

Authors:  Zhi-Xiang Yan; Xue-Jiao Gao; Ting Li; Bin Wei; Pan-Pan Wang; Ying Yang; Ru Yan
Journal:  Appl Environ Microbiol       Date:  2018-07-02       Impact factor: 4.792

5.  Pseudo-glutarylcarnitinaemia in medium-chain acyl-CoA dehydrogenase deficiency detected by tandem mass spectrometry newborn screening.

Authors:  N Napolitano; V Wiley; J J Pitt
Journal:  J Inherit Metab Dis       Date:  2004       Impact factor: 4.982

6.  Urinary metabotypes of newborns with perinatal asphyxia undergoing therapeutic hypothermia.

Authors:  Enrico Valerio; Veronica Mardegan; Matteo Stocchero; Maria Elena Cavicchiolo; Paola Pirillo; Gabriele Poloniato; Gianluca D'Onofrio; Luca Bonadies; Giuseppe Giordano; Eugenio Baraldi
Journal:  PLoS One       Date:  2022-08-16       Impact factor: 3.752
  6 in total

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