Literature DB >> 9298687

Specificities of anti-sialyl-Tn and anti-Tn monoclonal antibodies generated using novel clustered synthetic glycopeptide epitopes.

M A Reddish1, L Jackson, R R Koganty, D Qiu, W Hong, B M Longenecker.   

Abstract

The fine specificities of MAbs generated using novel synthetic clustered STn and Tn glycopeptides as immunogens were compared with the anti-TAG-72 antibodies B72.3 and CC49. Hapten inhibition experiments demonstrated the specificity of several of the MAbs for STn and Tn expressed on ovine submaxillary mucin and tumor derived MUC-1 mucin. Amongst the STn specific MAbs only the B195.3 MAb shows absolute dependence on the presence of sialic acid and specificity to the simple disaccharide NANAA alpha2-6-GalNAc. Identification of tumor associated carbohydrate epitopes in cluster and monomer configurations are possible using MAbs detecting the defined structure specificities described herein.

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Year:  1997        PMID： 9298687     DOI： 10.1023/a:1018576224062

Source DB:  PubMed          Journal:  Glycoconj J        ISSN： 0282-0080            Impact factor:   2.916


  26 in total

1.  Serum sialyl Tn as an independent predictor of poor prognosis in patients with epithelial ovarian cancer.

Authors:  H Kobayashi; T Terao; Y Kawashima
Journal:  J Clin Oncol       Date:  1992-01       Impact factor: 44.544

2.  Elucidation of an essential structure recognized by an anti-GalNAc alpha-Ser(Thr) monoclonal antibody (MLS 128).

Authors:  H Nakada; Y Numata; M Inoue; N Tanaka; H Kitagawa; I Funakoshi; S Fukui; I Yamashina
Journal:  J Biol Chem       Date:  1991-07-05       Impact factor: 5.157

3.  Immune sera and monoclonal antibodies define two configurations for the sialyl Tn tumor antigen.

Authors:  S Zhang; L A Walberg; S Ogata; S H Itzkowitz; R R Koganty; M Reddish; S S Gandhi; B M Longenecker; K O Lloyd; P O Livingston
Journal:  Cancer Res       Date:  1995-08-01       Impact factor: 12.701

4.  Quantitative and qualitative aspects of radiolocalization in colon cancer patients of intravenously administered MAb B72.3.

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Journal:  Int J Cancer       Date:  1987-01-15       Impact factor: 7.396

5.  Radioimmunoguided surgery using monoclonal antibody.

Authors:  E W Martin; C M Mojzisik; G H Hinkle; J Sampsel; M A Siddiqi; S E Tuttle; B Sickle-Santanello; D Colcher; M O Thurston; J G Bell
Journal:  Am J Surg       Date:  1988-11       Impact factor: 2.565

6.  Comparative dual label study of first and second generation antitumor-associated glycoprotein-72 monoclonal antibodies in colorectal cancer patients.

Authors:  S Gallinger; R M Reilly; J C Kirsh; R D Odze; B J Schmocker; K Hay; J Polihronis; M T Damani; B Shpitz; H S Stern
Journal:  Cancer Res       Date:  1993-01-15       Impact factor: 12.701

7.  A spectrum of monoclonal antibodies reactive with human mammary tumor cells.

Authors:  D Colcher; P H Hand; M Nuti; J Schlom
Journal:  Proc Natl Acad Sci U S A       Date:  1981-05       Impact factor: 11.205

8.  Preparation and characterization of monoclonal antibodies directed to the tumor-associated O-linked sialosyl-2----6 alpha-N-acetylgalactosaminyl (sialosyl-Tn) epitope.

Authors:  T Kjeldsen; H Clausen; S Hirohashi; T Ogawa; H Iijima; S Hakomori
Journal:  Cancer Res       Date:  1988-04-15       Impact factor: 12.701

9.  Alterations in gastric mucin with malignant transformation: novel pathway for mucin synthesis.

Authors:  Y Yamashita; Y S Chung; R Horie; R Kannagi; M Sowa
Journal:  J Natl Cancer Inst       Date:  1995-03-15       Impact factor: 13.506

10.  Generation and characterization of B72.3 second generation monoclonal antibodies reactive with the tumor-associated glycoprotein 72 antigen.

Authors:  R Muraro; M Kuroki; D Wunderlich; D J Poole; D Colcher; A Thor; J W Greiner; J F Simpson; A Molinolo; P Noguchi
Journal:  Cancer Res       Date:  1988-08-15       Impact factor: 12.701
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  20 in total

1.  Analysis of Tn antigenicity with a panel of new IgM and IgG1 monoclonal antibodies raised against leukemic cells.

Authors:  Ola Blixt; Olga I Lavrova; Dmitriy V Mazurov; Emiliano Cló; Stjepan K Kracun; Nicolai V Bovin; Alexander V Filatov
Journal:  Glycobiology       Date:  2011-12-05       Impact factor: 4.313

2.  Combined affinity and rate constant distributions of ligand populations from experimental surface binding kinetics and equilibria.

Authors:  Juraj Svitel; Andrea Balbo; Roy A Mariuzza; Noreen R Gonzales; Peter Schuck
Journal:  Biophys J       Date:  2003-06       Impact factor: 4.033

3.  Toward optimized carbohydrate-based anticancer vaccines: epitope clustering, carrier structure, and adjuvant all influence antibody responses to Lewis(y) conjugates in mice.

Authors:  V Kudryashov; P W Glunz; L J Williams; S Hintermann; S J Danishefsky; K O Lloyd
Journal:  Proc Natl Acad Sci U S A       Date:  2001-03-13       Impact factor: 11.205

4.  Module based antibody engineering: a novel synthetic REDantibody.

Authors:  Anatoliy Markiv; Bernard Anani; Ravi V Durvasula; Angray S Kang
Journal:  J Immunol Methods       Date:  2010-11-03       Impact factor: 2.303

Review 5.  Cancer vaccines and carbohydrate epitopes.

Authors:  Jamie Heimburg-Molinaro; Michelle Lum; Geraldine Vijay; Miten Jain; Adel Almogren; Kate Rittenhouse-Olson
Journal:  Vaccine       Date:  2011-10-01       Impact factor: 3.641

6.  Glycosylations versus conformational preferences of cancer associated mucin core.

Authors:  J Schuman; D Qiu; R R Koganty; B M Longenecker; A P Campbell
Journal:  Glycoconj J       Date:  2000-12       Impact factor: 2.916

Review 7.  Tumour-associated carbohydrate antigens in breast cancer.

Authors:  Aurélie Cazet; Sylvain Julien; Marie Bobowski; Joy Burchell; Philippe Delannoy
Journal:  Breast Cancer Res       Date:  2010-06-08       Impact factor: 6.466

8.  A rat model to study the role of STn antigen in colon cancer.

Authors:  S Ogata; I Ho; J Maklansky; A Chen; J L Werther; M Reddish; B M Longenecker; E Sigurdson; S Iishi; J Y Zhang; S H Itzkowitz
Journal:  Glycoconj J       Date:  2001 Nov-Dec       Impact factor: 2.916

Review 9.  The Cosmc connection to the Tn antigen in cancer.

Authors:  Tongzhong Ju; Rajindra P Aryal; Matthew R Kudelka; Yingchun Wang; Richard D Cummings
Journal:  Cancer Biomark       Date:  2014-01-01       Impact factor: 4.388

10.  A newly generated functional antibody identifies Tn antigen as a novel determinant in the cancer cell-lymphatic endothelium interaction.

Authors:  Carla Danussi; Anna Coslovi; Cristiana Campa; Maria T Mucignat; Paola Spessotto; Fulvio Uggeri; Sergio Paoletti; Alfonso Colombatti
Journal:  Glycobiology       Date:  2009-06-15       Impact factor: 4.313
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