OBJECTIVE: In adolescents, conduct disorder (CD), attention deficit hyperactivity disorder (ADHD), and depression are frequently comorbid with substance dependence (SD). We hypothesized that the prevalence and severity of CD, major depressive disorder (MDD), and ADHD would differ by gender, and that these conditions would associate differentially with severity of SD in males and females. METHODS: We examined these issues, using standardized diagnostic interviews, in 285 male and 82 female adolescents referred for comorbid CD and SD. RESULTS: Males and females did not differ significantly in severity of substance involvement, MDD, or ADHD, but males had more severe CD. MDD severity was the only variable significantly associated with SD severity for females, while for males, severity of CD combined with MDD and ADHD was significantly associated with SD severity. CONCLUSIONS: Among referred adolescents, CD, MDD, and ADHD may all be important concomitants of SD in males, while in females, depression may be the primary variable related to SD.
OBJECTIVE: In adolescents, conduct disorder (CD), attention deficit hyperactivity disorder (ADHD), and depression are frequently comorbid with substance dependence (SD). We hypothesized that the prevalence and severity of CD, major depressive disorder (MDD), and ADHD would differ by gender, and that these conditions would associate differentially with severity of SD in males and females. METHODS: We examined these issues, using standardized diagnostic interviews, in 285 male and 82 female adolescents referred for comorbid CD and SD. RESULTS: Males and females did not differ significantly in severity of substance involvement, MDD, or ADHD, but males had more severe CD. MDD severity was the only variable significantly associated with SD severity for females, while for males, severity of CD combined with MDD and ADHD was significantly associated with SD severity. CONCLUSIONS: Among referred adolescents, CD, MDD, and ADHD may all be important concomitants of SD in males, while in females, depression may be the primary variable related to SD.
Authors: Timothy E Wilens; MaryKate Martelon; Markus J P Kruesi; Tiffany Parcell; Diana Westerberg; Mary Schillinger; Martin Gignac; Joseph Biederman Journal: J Clin Psychiatry Date: 2009-02-10 Impact factor: 4.384
Authors: Jennifer M Zehe; Craig R Colder; Jennifer P Read; William F Wieczorek; Liliana J Lengua Journal: Addict Behav Date: 2012-12-13 Impact factor: 3.913
Authors: Carter R Petty; Michael C Monuteaux; Eric Mick; Samantha Hughes; Jacqueline Small; Stephen V Faraone; Joseph Biederman Journal: J Psychiatr Res Date: 2008-05-01 Impact factor: 4.791