UNLABELLED: To determine whether plasma levels of total bile acids may provide a useful index for hypergalactosaemia due to porto-systemic shunts, these levels were determined in hypergalactosaemic neonates. Increased levels were found in all cases with portohepatic venous or portocaval shunts. The levels of both total bile acids and galactose were normalized when the shunts disappeared on the echograms. Both bile acids and galactose are almost completely absorbed by the liver via the first portal blood passage. Portosystemic shunts contribute to elevated levels of bile acids and galactose. CONCLUSION: Increased plasma levels of total bile acids serve as a diagnostic clue to the presence of portosystemic shunts in neonates with hypergalactosaemia.
UNLABELLED: To determine whether plasma levels of total bile acids may provide a useful index for hypergalactosaemia due to porto-systemic shunts, these levels were determined in hypergalactosaemic neonates. Increased levels were found in all cases with portohepatic venous or portocaval shunts. The levels of both total bile acids and galactose were normalized when the shunts disappeared on the echograms. Both bile acids and galactose are almost completely absorbed by the liver via the first portal blood passage. Portosystemic shunts contribute to elevated levels of bile acids and galactose. CONCLUSION: Increased plasma levels of total bile acids serve as a diagnostic clue to the presence of portosystemic shunts in neonates with hypergalactosaemia.
Authors: Myung Jin Kim; Jae Sung Ko; Jeong Kee Seo; Hye Ran Yang; Ju Young Chang; Gi Beom Kim; Jung-Eun Cheon; Woo Sun Kim Journal: Eur J Pediatr Date: 2011-09-13 Impact factor: 3.183
Authors: Y Nishimura; G Tajima; A Dwi Bahagia; A Sakamoto; H Ono; N Sakura; K Naito; M Hamakawa; C Yoshii; M Kubota; K Kobayashi; T Saheki Journal: J Inherit Metab Dis Date: 2004 Impact factor: 4.982