Literature DB >> 9296375

Endotoxin regulates corticotropin-releasing hormone receptor 2 in heart and skeletal muscle.

K A Heldwein1, J E Duncan, P Stenzel, M B Rittenberg, M P Stenzel-Poore.   

Abstract

We tested the effect of endotoxin on the peripheral corticotropin-releasing hormone receptor (CRH-R2), which is highly expressed in the heart. Systemic injection of LPS markedly downregulated CRH-R2 mRNA levels in the heart in a dose and time dependent manner. In contrast, CRH-R2 levels in skeletal muscle increased following exposure to endotoxin. These results suggest that CRH-R2 may be differentially regulated in cardiac tissue and skeletal muscle. Finding that CRH-R2 expression in the heart is modulated by endotoxin, a potent inducer of cardiovascular dysregulation, suggests a possible link between CRH and the cardiovascular response to stress.

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Year:  1997        PMID： 9296375     DOI： 10.1016/s0303-7207(97)00103-2

Source DB:  PubMed          Journal:  Mol Cell Endocrinol        ISSN： 0303-7207            Impact factor:   4.102


  5 in total

1.  Corticotropin releasing factor 2 receptor agonists reduce the denervation-induced loss of rat skeletal muscle mass and force and increase non-atrophying skeletal muscle mass and force.

Authors:  R T Hinkle; E Donnelly; D B Cody; M B Bauer; R J Sheldon; R J Isfort
Journal:  J Muscle Res Cell Motil       Date:  2005-02-09       Impact factor: 2.698

Review 2.  Corticotropin-releasing factor signaling and visceral response to stress.

Authors:  Andreas Stengel; Yvette Taché
Journal:  Exp Biol Med (Maywood)       Date:  2010-10

3.  Expression and regulation of corticotropin-releasing factor receptor type 2β in developing and mature mouse skeletal muscle.

Authors:  Yael Kuperman; Orna Issler; Joan Vaughan; Louise Bilezikjian; Wylie Vale; Alon Chen
Journal:  Mol Endocrinol       Date:  2010-11-17

4.  Urocortins and CRF receptor type 2 variants in the male rat colon: gene expression and regulation by endotoxin and anti-inflammatory effect.

Authors:  Pu-Qing Yuan; S Vincent Wu; Charalabos Pothoulakis; Yvette Taché
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2016-01-07       Impact factor: 4.052

5.  A novel corticotropin-releasing factor receptor splice variant exhibits dominant negative activity: a putative link to stress-induced heart disease.

Authors:  Yehezkel Sztainberg; Yael Kuperman; Orna Issler; Shosh Gil; Joan Vaughan; Jean Rivier; Wylie Vale; Alon Chen
Journal:  FASEB J       Date:  2009-02-26       Impact factor: 5.191
  5 in total

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