PURPOSE: To determine the presence of small lesions in the pyramidal tract in patients with amyotrophic lateral sclerosis (ALS) by using magnetization-transfer (MT) measurements and MR imaging. METHODS: MT ratios (MTRs) were measured in the posterior limb of the internal capsule in nine patients with ALS and in nine healthy volunteers. RESULTS: The mean value of MTRs (%) in patients with ALS was 15.76 +/- 1.48, while that of the control subjects was 19.83 +/- 1.54. The difference was statistically significant. CONCLUSIONS: MT measurements are useful for detecting abnormalities associated with degeneration of the pyramidal tract in patients with ALS.
PURPOSE: To determine the presence of small lesions in the pyramidal tract in patients with amyotrophic lateral sclerosis (ALS) by using magnetization-transfer (MT) measurements and MR imaging. METHODS: MT ratios (MTRs) were measured in the posterior limb of the internal capsule in nine patients with ALS and in nine healthy volunteers. RESULTS: The mean value of MTRs (%) in patients with ALS was 15.76 +/- 1.48, while that of the control subjects was 19.83 +/- 1.54. The difference was statistically significant. CONCLUSIONS: MT measurements are useful for detecting abnormalities associated with degeneration of the pyramidal tract in patients with ALS.
Authors: F Agosta; A Chiò; M Cosottini; N De Stefano; A Falini; M Mascalchi; M A Rocca; V Silani; G Tedeschi; M Filippi Journal: AJNR Am J Neuroradiol Date: 2010-04-01 Impact factor: 3.825
Authors: M Cosottini; I Pesaresi; S Piazza; S Diciotti; G Belmonte; M Battaglini; A Ginestroni; G Siciliano; N De Stefano; M Mascalchi Journal: AJNR Am J Neuroradiol Date: 2011-03-24 Impact factor: 3.825
Authors: G Carrara; C Carapelli; F Venturi; M M Ferraris; L Lequio; A Chiò; A Calvo; S Sirgiovanni; A Cistaro; M C Valentini Journal: AJNR Am J Neuroradiol Date: 2011-12-22 Impact factor: 3.825