Literature DB >> 9295274

25-Hydroxyvitamin D3 1alpha-hydroxylase and vitamin D synthesis.

K Takeyama1, S Kitanaka, T Sato, M Kobori, J Yanagisawa, S Kato.   

Abstract

Renal 25-hydroxyvitamin D3 1alpha-hydroxylase [1alpha(OH)ase] catalyzes metabolic activation of 25-hydroxyvitamin D3 into 1alpha, 25-dihydroxyvitamin D3 [1alpha,25(OH)2D3], an active form of vitamin D, and is inhibited by 1alpha,25(OH)2D3. 1alpha(OH)ase, which was cloned from the kidney of mice lacking the vitamin D receptor (VDR-/- mice), is a member of the P450 family of enzymes (P450VD1alpha). Expression of 1alpha(OH)ase was suppressed by 1alpha, 25(OH)2D3 in VDR+/+ and VDR+/- mice but not in VDR-/- mice. These results indicate that the negative feedback regulation of active vitamin D synthesis is mediated by 1alpha(OH)ase through liganded VDR.

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Year:  1997        PMID： 9295274     DOI： 10.1126/science.277.5333.1827

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  101 in total

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