Literature DB >> 9295225

Opioids potentiate transmitter release from SK-N-SH human neuroblastoma cells by modulating N-type calcium channels.

O Keren1, M Gafni, Y Sarne.   

Abstract

Opioids induce dual (inhibitory and excitatory) regulation of depolarization-evoked [3H]dopamine release in SK-N-SH cells through either mu or delta receptors. The potentiation of dopamine release by opioid agonists is mediated by N-type voltage-dependent calcium channels and does not involve Gi/Go proteins. Removal of the excitatory opioid effect by blockade with omega-conotoxin, an N-channel antagonist, reveals the inhibitory effect of opioids on release, thus suggesting that both modulatory effects of opioids are exerted in parallel.

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Year:  1997        PMID： 9295225     DOI： 10.1016/s0006-8993(97)00599-4

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  4 in total

Review 1.  Neurotransmitter modulation of neuronal calcium channels.

Authors:  Keith S Elmslie
Journal:  J Bioenerg Biomembr       Date:  2003-12       Impact factor: 2.945

2.  G-protein-independent modulation of P-type calcium channels by mu-opioids in Purkinje neurons of rat.

Authors:  Olena Iegorova; Alexander Fisyunov; Oleg Krishtal
Journal:  Neurosci Lett       Date:  2010-06-10       Impact factor: 3.046

3.  Opioid and cannabinoid receptors share a common pool of GTP-binding proteins in cotransfected cells, but not in cells which endogenously coexpress the receptors.

Authors:  M Shapira; Z Vogel; Y Sarne
Journal:  Cell Mol Neurobiol       Date:  2000-06       Impact factor: 5.046

Review 4.  Opioid tolerance and the emergence of new opioid receptor-coupled signaling.

Authors:  A R Gintzler; S Chakrabarti
Journal:  Mol Neurobiol       Date:  2000 Feb-Apr       Impact factor: 5.682
  4 in total

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