| Literature DB >> 9295164 |
T G Lee1, J B Park, S D Lee, S Hong, J H Kim, Y Kim, K S Yi, S Bae, Y A Hannun, L M Obeid, P G Suh, S H Ryu.
Abstract
A phospholipase D1 (PLD1) was purified from rat brain by the use of antibody-coupled protein A Sepharose. We found that protein kinase C alp (PKCalpha) stimulated PLD1 activity in the presence of phorbol myristate acetate (PMA). PMA-dependent association of PKCalpha with PLD1 was verified in NIH-3T3 fibroblast cells, and COS7 cells transiently expressing PLD1 as well as in vitro suggesting that the activation of PLD1 resulted from direct association of PKCalpha with PLD1.Entities:
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Year: 1997 PMID： 9295164 DOI： 10.1016/s0005-2760(97)00083-0
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002