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Literature DB >> 9294894

Loss of oxyR in Mycobacterium tuberculosis.

Abstract

The loss of the putative regulator oxyR and the associated dysfunction of oxidative stress response in Mycobacterium tuberculosis may have coincided with, or directly participated in, the evolution of this microorganism into the potent contemporary human pathogen. These phenomena may have implications for host-pathogen interactions in tuberculosis and for M. tuberculosis sensitivity to the front-line antituberculosis agent isoniazid.

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Year: 1997 PMID： 9294894 DOI： 10.1016/S0966-842X(97)01112-8

Source DB: PubMed Journal: Trends Microbiol ISSN： 0966-842X Impact factor: 17.079

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Cited

15 in total

1. Alkyl hydroperoxide reductases C and D are major antigens constitutively expressed by Mycobacterium avium subsp. paratuberculosis.

Authors: I Olsen; L J Reitan; G Holstad; H G Wiker
Journal: Infect Immun Date: 2000-02 Impact factor: 3.441

2. Mutations prevalent among rifampin- and isoniazid-resistant Mycobacterium tuberculosis isolates from a hospital in Vietnam.

Authors: M Caws; Phan Minh Duy; Dau Quang Tho; Nguyen Thi Ngoc Lan; Dai Viet Hoa; Jeremy Farrar
Journal: J Clin Microbiol Date: 2006-07 Impact factor: 5.948

3. An altered Mycobacterium tuberculosis metabolome induced by katG mutations resulting in isoniazid resistance.

Authors: Du Toit Loots
Journal: Antimicrob Agents Chemother Date: 2014-01-27 Impact factor: 5.191

4. Regulation of the furA and catC operon, encoding a ferric uptake regulator homologue and catalase-peroxidase, respectively, in Streptomyces coelicolor A3(2).

Authors: J S Hahn; S Y Oh; J H Roe
Journal: J Bacteriol Date: 2000-07 Impact factor: 3.490

5. Silencing of oxidative stress response in Mycobacterium tuberculosis: expression patterns of ahpC in virulent and avirulent strains and effect of ahpC inactivation.

Authors: B Springer; S Master; P Sander; T Zahrt; M McFalone; J Song; K G Papavinasasundaram; M J Colston; E Boettger; V Deretic
Journal: Infect Immun Date: 2001-10 Impact factor: 3.441

Loss of oxyR in Mycobacterium tuberculosis.

1. Alkyl hydroperoxide reductases C and D are major antigens constitutively expressed by Mycobacterium avium subsp. paratuberculosis.

2. Mutations prevalent among rifampin- and isoniazid-resistant Mycobacterium tuberculosis isolates from a hospital in Vietnam.

3. An altered Mycobacterium tuberculosis metabolome induced by katG mutations resulting in isoniazid resistance.

4. Regulation of the furA and catC operon, encoding a ferric uptake regulator homologue and catalase-peroxidase, respectively, in Streptomyces coelicolor A3(2).

5. Silencing of oxidative stress response in Mycobacterium tuberculosis: expression patterns of ahpC in virulent and avirulent strains and effect of ahpC inactivation.

6. Transcriptional regulation of furA and katG upon oxidative stress in Mycobacterium smegmatis.

7. Mapping of Mycobacterium tuberculosis katG promoters and their differential expression in infected macrophages.

8. Oxidative stress response and characterization of the oxyR-ahpC and furA-katG loci in Mycobacterium marinum.

9. Molecular and physiological effects of mycobacterial oxyR inactivation.

10. Global effects of inactivation of the pyruvate kinase gene in the Mycobacterium tuberculosis complex.